SEC22B protein (Oryctolagus cuniculus) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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[Homology]

Score

SEC22B

SEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (219 aa)

Predicted Functional Partners:

GOSR2

0.999

STX18

0.999

BET1

0.998

BNIP1

0.992

SCFD1

0.986

STX4

0.980

YKT6

0.978

SEC24A

0.977

GOSR1

0.967

STX7

0.965

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BET1	BNIP1	ENSOCUP00000047270	ENSOCUP00000000037	Bet1 golgi vesicular membrane trafficking protein.	BCL2 interacting protein 1.	0.456
BET1	GOSR1	ENSOCUP00000047270	ENSOCUP00000001528	Bet1 golgi vesicular membrane trafficking protein.	Golgi SNAP receptor complex member 1.	0.985
BET1	GOSR2	ENSOCUP00000047270	ENSOCUP00000033253	Bet1 golgi vesicular membrane trafficking protein.	Uncharacterized protein; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.	0.998
BET1	SCFD1	ENSOCUP00000047270	ENSOCUP00000006775	Bet1 golgi vesicular membrane trafficking protein.	Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family.	0.973
BET1	SEC22B	ENSOCUP00000047270	ENSOCUP00000049216	Bet1 golgi vesicular membrane trafficking protein.	SEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family.	0.998
BET1	SEC24A	ENSOCUP00000047270	ENSOCUP00000007143	Bet1 golgi vesicular membrane trafficking protein.	SEC24 homolog A, COPII coat complex component.	0.792
BET1	STX18	ENSOCUP00000047270	ENSOCUP00000034682	Bet1 golgi vesicular membrane trafficking protein.	Syntaxin 18.	0.689
BET1	STX4	ENSOCUP00000047270	ENSOCUP00000041354	Bet1 golgi vesicular membrane trafficking protein.	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family.	0.495
BET1	STX7	ENSOCUP00000047270	ENSOCUP00000028173	Bet1 golgi vesicular membrane trafficking protein.	Syntaxin 7; Belongs to the syntaxin family.	0.863
BET1	YKT6	ENSOCUP00000047270	ENSOCUP00000002592	Bet1 golgi vesicular membrane trafficking protein.	Uncharacterized protein.	0.984
BNIP1	BET1	ENSOCUP00000000037	ENSOCUP00000047270	BCL2 interacting protein 1.	Bet1 golgi vesicular membrane trafficking protein.	0.456
BNIP1	GOSR1	ENSOCUP00000000037	ENSOCUP00000001528	BCL2 interacting protein 1.	Golgi SNAP receptor complex member 1.	0.546
BNIP1	GOSR2	ENSOCUP00000000037	ENSOCUP00000033253	BCL2 interacting protein 1.	Uncharacterized protein; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.	0.648
BNIP1	SCFD1	ENSOCUP00000000037	ENSOCUP00000006775	BCL2 interacting protein 1.	Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family.	0.735
BNIP1	SEC22B	ENSOCUP00000000037	ENSOCUP00000049216	BCL2 interacting protein 1.	SEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family.	0.992
BNIP1	STX18	ENSOCUP00000000037	ENSOCUP00000034682	BCL2 interacting protein 1.	Syntaxin 18.	0.995
BNIP1	STX7	ENSOCUP00000000037	ENSOCUP00000028173	BCL2 interacting protein 1.	Syntaxin 7; Belongs to the syntaxin family.	0.446
BNIP1	YKT6	ENSOCUP00000000037	ENSOCUP00000002592	BCL2 interacting protein 1.	Uncharacterized protein.	0.614
GOSR1	BET1	ENSOCUP00000001528	ENSOCUP00000047270	Golgi SNAP receptor complex member 1.	Bet1 golgi vesicular membrane trafficking protein.	0.985
GOSR1	BNIP1	ENSOCUP00000001528	ENSOCUP00000000037	Golgi SNAP receptor complex member 1.	BCL2 interacting protein 1.	0.546

page 1 of 5

Network Stats

number of nodes:

5

number of edges:

5

average node degree:

2

avg. local clustering coefficient:

0.833

expected number of edges:

4

PPI enrichment p-value:

0.377

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006072

glycerol-3-phosphate metabolic process

5 of 12

2.91

5.03

4.40e-10

GO:0019432

Triglyceride biosynthetic process

4 of 13

2.77

3.76

1.03e-07

GO:0006654

Phosphatidic acid biosynthetic process

4 of 17

2.66

3.55

2.15e-07

GO:0008654

Phospholipid biosynthetic process

7 of 183

1.87

3.48

2.42e-09

GO:0046486

Glycerolipid metabolic process

8 of 318

1.69

3.11

1.24e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008374

O-acyltransferase activity

8 of 49

2.5

7.29

7.90e-16

GO:0003841

1-acylglycerol-3-phosphate O-acyltransferase activity

5 of 11

2.94

5.55

4.61e-11

GO:0004366

glycerol-3-phosphate O-acyltransferase activity

4 of 5

3.19

4.79

1.85e-09

GO:0102420

sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity

2 of 2

3.29

1.86

0.00044

GO:0003824

Catalytic activity

11 of 5987

0.55

0.46

0.00030

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009331

glycerol-3-phosphate dehydrogenase complex

2 of 4

2.99

1.24

0.0057

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:31159297

(2019) Functional Analysis of Genes Involved in Glycerolipids Biosynthesis (GPAT1 and GPAT2) in Pigs.

4 of 14

2.74

2.79

7.12e-06

PMID:38003015

(2023) Role of Different Members of the AGPAT Gene Family in Milk Fat Synthesis in Bubalus bubalis.

4 of 17

2.66

2.77

7.12e-06

PMID:29724161

(2018) Transcriptional profiling of swine mammary gland during the transition from colostrogenesis to lactogenesis using RNA sequencing.

5 of 95

2.01

2.29

1.89e-05

PMID:28455945

(2017) The influence of delipidation on triglyceride and LIPIN1 of porcine embryos derived from parthenogenetic activation.

3 of 6

2.99

2.14

0.00013

PMID:36108237

(2022) Identification of a missense variant in the porcine AGPAT gene family associated with intramuscular fat content through whole-genome sequencing.

3 of 8

2.86

2.03

0.00020

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10409

Glycerophospholipid metabolism

10 of 31

2.8

11.45

1.04e-23

CL:10458

glycerol-3-phosphate O-acyltransferase activity, and glycerol-3-phosphate catabolic process

6 of 6

3.29

7.99

2.10e-15

CL:10411

Glycerolipid metabolism

3 of 19

2.48

2.17

8.74e-05

CL:10412

Mixed, incl. Acyltransferase C-terminus, and Diacylglycerol diphosphate phosphatase activity

2 of 11

2.55

1.14

0.0084

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ssc00564

Glycerophospholipid metabolism

11 of 84

2.4

10.09

2.53e-24

ssc00561

Glycerolipid metabolism

7 of 53

2.41

6.33

5.31e-14

ssc01100

Metabolic pathways

8 of 1250

1.09

1.26

2.25e-06

ssc04975

Fat digestion and absorption

2 of 37

2.02

0.97

0.0147

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

SSC-1483166

Synthesis of PA

10 of 38

2.71

11.04

2.18e-23

SSC-1430728

Metabolism

11 of 1426

1.17

1.77

4.08e-11

SSC-75109

Triglyceride biosynthesis

2 of 11

2.55

1.26

0.0050

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009331

glycerol-3-phosphate dehydrogenase complex

2 of 4

2.99

1.18

0.0073

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0012

Acyltransferase

4 of 73

2.03

2.26

2.30e-05

KW-0594

Phospholipid biosynthesis

2 of 10

2.59

1.34

0.0036

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07479

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus

2 of 3

3.11

1.26

0.0054

PF01210

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus

2 of 3

3.11

1.26

0.0054

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002123

Phospholipid/glycerol acyltransferase

8 of 14

3.04

9.79

3.12e-19

IPR022284

Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase

3 of 4

3.16

2.73

1.11e-05

IPR045520

GPAT/DHAPAT, C-terminal domain

2 of 2

3.29

1.4

0.0030

IPR045252

Lysophosphatidylcholine acyltransferase LPCAT1-like

2 of 4

2.99

1.4

0.0030

IPR041728

GPAT/DHAPAT, acyltransferase domain

2 of 2

3.29

1.4

0.0030

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00563

Phosphate acyltransferases

8 of 19

2.91

9.63

2.83e-19

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