node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FEN1 | H3BWP1_TETNG | ENSTNIP00000005494 | ENSTNIP00000000404 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.715 |
FEN1 | H3CBP7_TETNG | ENSTNIP00000005494 | ENSTNIP00000005669 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Thymine DNA glycosylase, tandem duplicate 2. | 0.492 |
FEN1 | H3D5X1_TETNG | ENSTNIP00000005494 | ENSTNIP00000015911 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | AP_endonuc_2 domain-containing protein. | 0.584 |
FEN1 | H3DD39_TETNG | ENSTNIP00000005494 | ENSTNIP00000018432 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.994 |
FEN1 | H3DKM8_TETNG | ENSTNIP00000005494 | ENSTNIP00000021075 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 8-oxoguanine DNA glycosylase. | 0.620 |
FEN1 | MUTYH | ENSTNIP00000005494 | ENSTNIP00000013608 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | 0.537 |
FEN1 | NTHL1 | ENSTNIP00000005494 | ENSTNIP00000017080 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | 0.653 |
FEN1 | UNG | ENSTNIP00000005494 | ENSTNIP00000018961 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.860 |
H3BWP1_TETNG | FEN1 | ENSTNIP00000000404 | ENSTNIP00000005494 | Uncharacterized protein. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.715 |
H3BWP1_TETNG | H3C768_TETNG | ENSTNIP00000000404 | ENSTNIP00000004089 | Uncharacterized protein. | Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family. | 0.751 |
H3BWP1_TETNG | H3CBP7_TETNG | ENSTNIP00000000404 | ENSTNIP00000005669 | Uncharacterized protein. | Thymine DNA glycosylase, tandem duplicate 2. | 0.721 |
H3BWP1_TETNG | H3D5X1_TETNG | ENSTNIP00000000404 | ENSTNIP00000015911 | Uncharacterized protein. | AP_endonuc_2 domain-containing protein. | 0.795 |
H3BWP1_TETNG | H3DD39_TETNG | ENSTNIP00000000404 | ENSTNIP00000018432 | Uncharacterized protein. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.814 |
H3BWP1_TETNG | H3DKM8_TETNG | ENSTNIP00000000404 | ENSTNIP00000021075 | Uncharacterized protein. | 8-oxoguanine DNA glycosylase. | 0.798 |
H3BWP1_TETNG | MUTYH | ENSTNIP00000000404 | ENSTNIP00000013608 | Uncharacterized protein. | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | 0.801 |
H3BWP1_TETNG | NTHL1 | ENSTNIP00000000404 | ENSTNIP00000017080 | Uncharacterized protein. | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | 0.838 |
H3BWP1_TETNG | Q4T029_TETNG | ENSTNIP00000000404 | ENSTNIP00000008006 | Uncharacterized protein. | Small nuclear ribonucleoprotein Sm D3. | 0.781 |
H3BWP1_TETNG | UNG | ENSTNIP00000000404 | ENSTNIP00000018961 | Uncharacterized protein. | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.770 |
H3C768_TETNG | H3BWP1_TETNG | ENSTNIP00000004089 | ENSTNIP00000000404 | Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family. | Uncharacterized protein. | 0.751 |
H3C768_TETNG | Q4T029_TETNG | ENSTNIP00000004089 | ENSTNIP00000008006 | Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family. | Small nuclear ribonucleoprotein Sm D3. | 0.999 |