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Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
H3BYK6_TETNGRubicon autophagy regulator. (893 aa)    
Predicted Functional Partners:
H3CDN0_TETNG
UV radiation resistance associated gene.
    
 0.997
H3CAL5_TETNG
Phosphoinositide-3-kinase, regulatory subunit 4.
    
 
 0.974
H3DNZ6_TETNG
Phosphatidylinositol 3-kinase catalytic subunit type 3.
    
 
 0.974
H3D1Y5_TETNG
Beclin 1, autophagy related.
    
 
 0.948
H3BW56_TETNG
Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.
    
   0.765
H3D0L3_TETNG
RAB7a, member RAS oncogene family.
    
 
 0.691
RAB7A
Chromosome 11 SCAF14979, whole genome shotgun sequence.
    
 
 0.691
ARL8B
ADP ribosylation factor like GTPase 8B; Belongs to the small GTPase superfamily. Arf family.
    
 
 0.659
Q4RXA5_TETNG
Chromosome 11 SCAF14979, whole genome shotgun sequence; Belongs to the small GTPase superfamily. Arf family.
    
 
 0.659
H3DBF4_TETNG
Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]
   
  
 0.633
Your Current Organism:
Tetraodon nigroviridis
NCBI taxonomy Id: 99883
Other names: T. nigroviridis, spotted green pufferfish
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