Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
H3BZ42_TETNGUncharacterized protein. (531 aa)    
Predicted Functional Partners:
H3CLI2_TETNG
Retinoid X receptor, alpha a.
    
0.980
H3DM70_TETNG
Retinoid x receptor, beta b.
    
0.972
RXRB
Retinoid X receptor beta.
    
0.944
H3CFE0_TETNG
Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    
 0.939
HDAC3
Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). May play a role in the regulation of the circadian clock in a deacetylase activity-independent manner (By similarity).
    
 0.925
H3CW30_TETNG
Nuclear receptor subfamily 1, group H, member 3.
    
 0.916
H3CE10_TETNG
Phospholipase A2, group XV.
     
 0.911
H3C8P2_TETNG
RRM domain-containing protein.
    
 0.908
H3D182_TETNG
Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.
    
 0.908
H3D6D6_TETNG
Deacetylase sirtuin-type domain-containing protein.
    
 0.907
Your Current Organism:
Tetraodon nigroviridis
NCBI taxonomy Id: 99883
Other names: T. nigroviridis, spotted green pufferfish
Server load: low (8%) [HD]