STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HIST1H4CHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)    
Predicted Functional Partners:
H3CVV4_TETNG
LEO1 homolog, Paf1/RNA polymerase II complex component.
    
 
 0.808
H3DHR2_TETNG
Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG.
    
 0.807
H3CA73_TETNG
AT rich interactive domain 4A (RBP1-like).
    
 0.794
H3DGW8_TETNG
Translocase of outer mitochondrial membrane 20.
    
 0.794
H3CF69_TETNG
H2A histone family, member Y2; Belongs to the histone H2A family.
   
 0.785
H3DFA2_TETNG
H2A histone family, member Y; Belongs to the histone H2A family.
 
 
 0.785
H3CL24_TETNG
Myb-like, SWIRM and MPN domains 1.
    
 0.769
H2AZ1
Histone H2A; Belongs to the histone H2A family.
   
 0.733
H3DDW0_TETNG
Histone H2A; Belongs to the histone H2A family.
   
 0.733
H3CJ02_TETNG
Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
    
 0.731
Your Current Organism:
Tetraodon nigroviridis
NCBI taxonomy Id: 99883
Other names: T. nigroviridis, spotted green pufferfish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.