STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
H3D1Z9_TETNGNa(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (385 aa)    
Predicted Functional Partners:
H3DF59_TETNG
Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.
   
 0.649
H3CQI9_TETNG
Intraflagellar transport 80 homolog (Chlamydomonas).
    
 0.523
H3CM13_TETNG
Intraflagellar transport 57 homolog (Chlamydomonas).
    
 0.511
H3CU11_TETNG
TNF receptor-associated factor 3 interacting protein 1.
    
 0.510
H3CIP1_TETNG
Intraflagellar transport 172.
    
 0.500
H3CIK5_TETNG
Uncharacterized protein.
    
 
 0.494
H3DE04_TETNG
Intraflagellar transport 88 homolog.
    
 0.485
H3DAM6_TETNG
Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family.
    
 0.463
H3D1K4_TETNG
Intraflagellar transport 81 homolog.
    
 0.443
H3C6F2_TETNG
Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
    
 0.419
Your Current Organism:
Tetraodon nigroviridis
NCBI taxonomy Id: 99883
Other names: T. nigroviridis, spotted green pufferfish
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