STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
H3DF59_TETNGCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1508 aa)    
Predicted Functional Partners:
H3CP76_TETNG
Golgi-associated PDZ and coiled-coil motif containing.
   
 0.925
H3CVC6_TETNG
Ubiquitin carboxyl-terminal hydrolase.
    
 0.887
H3DD70_TETNG
Valosin containing protein; Belongs to the AAA ATPase family.
   
 0.845
H3D5J4_TETNG
STIP1 homology and U-Box containing protein 1.
    
 
 0.815
H3DP20_TETNG
Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.
    
 0.756
RNF5
Ring finger protein 5.
    
 0.732
Q4SJC5_TETNG
Chromosome 4 SCAF14575, whole genome shotgun sequence.
    
 0.732
H3D8U4_TETNG
PDZ domain containing 1.
   
 0.700
H3C9Q5_TETNG
Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.
   
 0.649
H3CB97_TETNG
PDZ domain-containing protein.
   
 0.649
Your Current Organism:
Tetraodon nigroviridis
NCBI taxonomy Id: 99883
Other names: T. nigroviridis, spotted green pufferfish
Server load: low (22%) [HD]