EMD17278.1 protein (Eggerthia catenaformis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

EMD17278.1

Hypothetical protein. (475 aa)

Predicted Functional Partners:

EMD16418.1

0.959

EMD16375.1

0.954

EMD16419.1

0.931

EMD16051.1

0.926

guaA

0.901

EMD17279.1

0.775

EMD17270.1

0.641

asnS

0.621

EMD17273.1

0.596

EMD17271.1

0.584

Your Current Organism:

Eggerthia catenaformis

NCBI taxonomy Id: 999415
Other names: E. catenaformis OT 569 = DSM 20559, Eggerthia catenaformis DSM 20559, Eggerthia catenaformis OT 569, Eggerthia catenaformis OT 569 = DSM 20559, Lactobacillus catenaformis DSM 20559 = OT 569, Lactobacillus catenaformis OT 569

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EMD16051.1	EMD16375.1	HMPREF9943_01454	HMPREF9943_01301	Hypothetical protein.	Hypothetical protein.	0.593
EMD16051.1	EMD16418.1	HMPREF9943_01454	HMPREF9943_01344	Hypothetical protein.	Hypothetical protein.	0.541
EMD16051.1	EMD16419.1	HMPREF9943_01454	HMPREF9943_01345	Hypothetical protein.	Hypothetical protein.	0.521
EMD16051.1	EMD17278.1	HMPREF9943_01454	HMPREF9943_00431	Hypothetical protein.	Hypothetical protein.	0.926
EMD16051.1	EMD17279.1	HMPREF9943_01454	HMPREF9943_00432	Hypothetical protein.	Hypothetical protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.564
EMD16375.1	EMD16051.1	HMPREF9943_01301	HMPREF9943_01454	Hypothetical protein.	Hypothetical protein.	0.593
EMD16375.1	EMD16418.1	HMPREF9943_01301	HMPREF9943_01344	Hypothetical protein.	Hypothetical protein.	0.998
EMD16375.1	EMD16419.1	HMPREF9943_01301	HMPREF9943_01345	Hypothetical protein.	Hypothetical protein.	0.991
EMD16375.1	EMD17278.1	HMPREF9943_01301	HMPREF9943_00431	Hypothetical protein.	Hypothetical protein.	0.954
EMD16418.1	EMD16051.1	HMPREF9943_01344	HMPREF9943_01454	Hypothetical protein.	Hypothetical protein.	0.541
EMD16418.1	EMD16375.1	HMPREF9943_01344	HMPREF9943_01301	Hypothetical protein.	Hypothetical protein.	0.998
EMD16418.1	EMD16419.1	HMPREF9943_01344	HMPREF9943_01345	Hypothetical protein.	Hypothetical protein.	0.999
EMD16418.1	EMD17278.1	HMPREF9943_01344	HMPREF9943_00431	Hypothetical protein.	Hypothetical protein.	0.959
EMD16418.1	EMD17279.1	HMPREF9943_01344	HMPREF9943_00432	Hypothetical protein.	Hypothetical protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.442
EMD16418.1	guaA	HMPREF9943_01344	HMPREF9943_00641	Hypothetical protein.	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	0.594
EMD16419.1	EMD16051.1	HMPREF9943_01345	HMPREF9943_01454	Hypothetical protein.	Hypothetical protein.	0.521
EMD16419.1	EMD16375.1	HMPREF9943_01345	HMPREF9943_01301	Hypothetical protein.	Hypothetical protein.	0.991
EMD16419.1	EMD16418.1	HMPREF9943_01345	HMPREF9943_01344	Hypothetical protein.	Hypothetical protein.	0.999
EMD16419.1	EMD17278.1	HMPREF9943_01345	HMPREF9943_00431	Hypothetical protein.	Hypothetical protein.	0.931
EMD16419.1	guaA	HMPREF9943_01345	HMPREF9943_00641	Hypothetical protein.	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	0.586

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.736

expected number of edges:

24

PPI enrichment p-value:

0.0777

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005977

Glycogen metabolic process

9 of 45

2.6

8.73

1.08e-18

GO:0005979

Regulation of glycogen biosynthetic process

5 of 14

2.85

5.27

1.32e-10

GO:0005978

Glycogen biosynthetic process

3 of 17

2.54

2.27

6.00e-05

GO:0043153

Entrainment of circadian clock by photoperiod

3 of 21

2.45

2.15

9.25e-05

GO:0032922

Circadian regulation of gene expression

3 of 70

1.93

1.34

0.0022

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030247

Polysaccharide binding

5 of 23

2.63

4.44

3.46e-09

GO:2001069

Glycogen binding

4 of 7

3.05

4.32

1.21e-08

GO:0008157

Protein phosphatase 1 binding

5 of 33

2.48

4.13

8.82e-09

GO:0061547

Glycogen synthase activity, transferring glucose-1-phosphate

2 of 4

2.99

1.56

0.0015

GO:0004373

Glycogen (starch) synthase activity

2 of 5

2.9

1.53

0.0017

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000164

Protein phosphatase type 1 complex

7 of 18

2.88

8.0

5.43e-16

GO:0008287

Protein serine/threonine phosphatase complex

8 of 56

2.45

7.24

5.43e-16

GO:0072357

PTW/PP1 phosphatase complex

3 of 6

2.99

3.07

2.51e-06

GO:1902494

Catalytic complex

9 of 1608

1.04

1.2

1.28e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:19707

Protein phosphatase type 1 complex, and cGMP-dependent protein kinase interacting domain

9 of 15

3.07

11.54

1.15e-22

CL:19726

Glycogen binding

5 of 5

3.3

6.44

1.70e-12

CL:19711

PTW/PP1 phosphatase complex, and cGMP-dependent protein kinase interacting domain

3 of 6

2.99

2.95

4.24e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

oaa04910

Insulin signaling pathway

11 of 92

2.37

9.82

5.23e-24

oaa04931

Insulin resistance

9 of 76

2.37

7.98

1.26e-18

oaa05031

Amphetamine addiction

3 of 45

2.12

1.91

0.00018

oaa04720

Long-term potentiation

3 of 45

2.12

1.91

0.00018

oaa03015

mRNA surveillance pathway

3 of 53

2.05

1.88

0.00018

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8982491

Glycogen metabolism

5 of 40

2.39

3.87

2.35e-08

MAP-3322077

Glycogen synthesis

4 of 20

2.6

3.44

3.18e-07

MAP-71387

Metabolism of carbohydrates

5 of 348

1.45

1.41

0.00027

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000164

Protein phosphatase type 1 complex

4 of 16

2.69

3.72

1.08e-07

GOCC:0008287

Protein serine/threonine phosphatase complex

5 of 55

2.25

3.45

1.08e-07

GOCC:0032154

Cleavage furrow

2 of 29

2.13

0.77

0.0373

GOCC:1902494

Catalytic complex

6 of 1635

0.86

0.51

0.0266

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0320

Glycogen biosynthesis

2 of 4

2.99

1.8

0.00055

KW-0464

Manganese

3 of 41

2.16

1.76

0.00040

KW-0904

Protein phosphatase

3 of 58

2.01

1.65

0.00055

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16760

Starch/carbohydrate-binding module (family 53)

4 of 6

3.12

4.28

1.55e-08

PF05693

Glycogen synthase

2 of 4

2.99

1.35

0.0036

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR038175

CBM21 domain superfamily

2 of 2

3.3

1.22

0.0065

IPR031675

Serine-threonine protein phosphatase, N-terminal

2 of 2

3.3

1.22

0.0065

IPR005036

CBM21 (carbohydrate binding type-21) domain

2 of 2

3.3

1.22

0.0065

IPR006186

Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase

2 of 8

2.69

1.05

0.0122

IPR004843

Calcineurin-like phosphoesterase domain, ApaH type

2 of 19

2.32

0.73

0.0455

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00156

Protein phosphatase 2A homologues, catalytic domain.

3 of 13

2.66

2.39

3.79e-05

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