STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (661 aa)    
Predicted Functional Partners:
TDIS_0637
Acetyl-coenzyme A carboxyl transferase alpha chain.
    
 0.949
TDIS_0890
Putative acetyl-CoA synthetase; (ADP-forming) alpha and beta chains.
    
 0.922
TDIS_1464
2-oxoglutarate oxidoreductase, alpha subunit.
  
 
 0.918
TDIS_1006
5,10-methylenetetrahydrofolate reductase.
   
 
 0.894
TDIS_0675
Pyruvate carboxyl transferase subunit B.
  
 
 0.870
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
 
 0.865
TDIS_0931
(R)-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.865
TDIS_1008
Acetyl-CoA synthase corrinoid iron-sulfur protein, large subunit.
   
 
 0.863
TDIS_0149
Pyruvate:ferredoxin oxidoreductase, delta subunit.
   
 
 0.861
TDIS_0148
Pyruvate:ferredoxin oxidoreductase, alpha subunit.
  
 
 0.859
Your Current Organism:
Thermosulfurimonas dismutans
NCBI taxonomy Id: 999894
Other names: DSM 24515, T. dismutans, Thermodesulfobacteriaceae bacterium S95, Thermosulfurimonas dismutans Slobodkin et al. 2012, VKM B-2683, strain S95
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