STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TDIS_1188Amino acid-binding ACT. (148 aa)    
Predicted Functional Partners:
TDIS_1189
Phenylacetate-coenzyme A ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).
 
   0.927
TDIS_0071
Chorismate mutase I.
    
  0.838
TDIS_0444
Indolepyruvate oxidoreductase subunit IorA; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
 
    0.678
TDIS_0442
Phenylacetate-coenzyme A ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).
 
   0.663
TDIS_0618
Phenylacetate-coenzyme A ligase.
 
   0.653
TDIS_0443
Indolepyruvate oxidoreductase subunit IorB.
 
    0.650
TDIS_1146
Putative homoserine kinase.
  
  
  0.587
TDIS_1190
Hypothetical protein.
       0.572
TDIS_1191
Hypothetical protein.
       0.558
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
     
  0.499
Your Current Organism:
Thermosulfurimonas dismutans
NCBI taxonomy Id: 999894
Other names: DSM 24515, T. dismutans, Thermodesulfobacteriaceae bacterium S95, Thermosulfurimonas dismutans Slobodkin et al. 2012, VKM B-2683, strain S95
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