node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
glyA | guaA | CEB3_c41940 | CEB3_c34990 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.910 |
glyA | pabB | CEB3_c41940 | CEB3_c24160 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Aminodeoxychorismate synthase component 1. | 0.602 |
glyA | trpA | CEB3_c41940 | CEB3_c03830 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.837 |
glyA | trpB | CEB3_c41940 | CEB3_c03840 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.831 |
glyA | trpC | CEB3_c41940 | CEB3_c23570 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.631 |
glyA | trpF | CEB3_c41940 | CEB3_c23580 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. | 0.672 |
guaA | glyA | CEB3_c34990 | CEB3_c41940 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.910 |
guaA | hisE | CEB3_c34990 | CEB3_c01120 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. | 0.532 |
guaA | pabA | CEB3_c34990 | CEB3_c03860 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Aminodeoxychorismate/anthranilate synthase component 2. | 0.530 |
guaA | pabB | CEB3_c34990 | CEB3_c24160 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Aminodeoxychorismate synthase component 1. | 0.801 |
guaA | trpA | CEB3_c34990 | CEB3_c03830 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.835 |
guaA | trpB | CEB3_c34990 | CEB3_c03840 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.860 |
guaA | trpD | CEB3_c34990 | CEB3_c03850 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.475 |
guaA | trpE | CEB3_c34990 | CEB3_c03870 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Anthranilate synthase component 1. | 0.698 |
guaA | trpF | CEB3_c34990 | CEB3_c23580 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. | 0.587 |
hisE | guaA | CEB3_c01120 | CEB3_c34990 | phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.532 |
hisE | pabA | CEB3_c01120 | CEB3_c03860 | phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. | Aminodeoxychorismate/anthranilate synthase component 2. | 0.555 |
hisE | pabB | CEB3_c01120 | CEB3_c24160 | phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. | Aminodeoxychorismate synthase component 1. | 0.790 |
hisE | trpA | CEB3_c01120 | CEB3_c03830 | phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.832 |
hisE | trpB | CEB3_c01120 | CEB3_c03840 | phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.808 |