Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AIMP2 | C19orf57 | ENSP00000223029 | ENSP00000254336 | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. | Uncharacterized protein C19orf57; Chromosome 19 open reading frame 57. | 0.617 |
| C19orf57 | AIMP2 | ENSP00000254336 | ENSP00000223029 | Uncharacterized protein C19orf57; Chromosome 19 open reading frame 57. | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. | 0.617 |
| C19orf57 | C19orf67 | ENSP00000254336 | ENSP00000449137 | Uncharacterized protein C19orf57; Chromosome 19 open reading frame 57. | UPF0575 protein C19orf67; Chromosome 19 open reading frame 67; Belongs to the UPF0575 family. | 0.541 |
| C19orf57 | F11 | ENSP00000254336 | ENSP00000384957 | Uncharacterized protein C19orf57; Chromosome 19 open reading frame 57. | Coagulation factor XIa heavy chain; Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. | 0.610 |
| C19orf57 | HSF2BP | ENSP00000254336 | ENSP00000291560 | Uncharacterized protein C19orf57; Chromosome 19 open reading frame 57. | Heat shock factor 2-binding protein; May be involved in modulating HSF2 activation in testis. Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity). | 0.793 |
| C19orf57 | KRTAP10-9 | ENSP00000254336 | ENSP00000381009 | Uncharacterized protein C19orf57; Chromosome 19 open reading frame 57. | Keratin-associated protein 10-9; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. | 0.463 |
| C19orf57 | MEIOB | ENSP00000254336 | ENSP00000314484 | Uncharacterized protein C19orf57; Chromosome 19 open reading frame 57. | Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity i [...] | 0.615 |
| C19orf57 | PRCC | ENSP00000254336 | ENSP00000271526 | Uncharacterized protein C19orf57; Chromosome 19 open reading frame 57. | Proline-rich protein PRCC; May regulate cell cycle progression through interaction with MAD2L2. | 0.626 |
| C19orf57 | SPATA22 | ENSP00000254336 | ENSP00000459580 | Uncharacterized protein C19orf57; Chromosome 19 open reading frame 57. | Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I. | 0.620 |
| C19orf57 | SYCP3 | ENSP00000254336 | ENSP00000376658 | Uncharacterized protein C19orf57; Chromosome 19 open reading frame 57. | Synaptonemal complex protein 3; Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells (By similarity). Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity). Belongs to the XLR/SYCP3 family. | 0.470 |
| C19orf57 | TKTL2 | ENSP00000254336 | ENSP00000280605 | Uncharacterized protein C19orf57; Chromosome 19 open reading frame 57. | Transketolase-like protein 2; Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis; Belongs to the transketolase family. | 0.610 |
| C19orf67 | C19orf57 | ENSP00000449137 | ENSP00000254336 | UPF0575 protein C19orf67; Chromosome 19 open reading frame 67; Belongs to the UPF0575 family. | Uncharacterized protein C19orf57; Chromosome 19 open reading frame 57. | 0.541 |
| F11 | C19orf57 | ENSP00000384957 | ENSP00000254336 | Coagulation factor XIa heavy chain; Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. | Uncharacterized protein C19orf57; Chromosome 19 open reading frame 57. | 0.610 |
| F11 | PRCC | ENSP00000384957 | ENSP00000271526 | Coagulation factor XIa heavy chain; Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. | Proline-rich protein PRCC; May regulate cell cycle progression through interaction with MAD2L2. | 0.629 |
| HSF2BP | C19orf57 | ENSP00000291560 | ENSP00000254336 | Heat shock factor 2-binding protein; May be involved in modulating HSF2 activation in testis. Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity). | Uncharacterized protein C19orf57; Chromosome 19 open reading frame 57. | 0.793 |
| HSF2BP | MEIOB | ENSP00000291560 | ENSP00000314484 | Heat shock factor 2-binding protein; May be involved in modulating HSF2 activation in testis. Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity). | Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity i [...] | 0.691 |
| HSF2BP | SPATA22 | ENSP00000291560 | ENSP00000459580 | Heat shock factor 2-binding protein; May be involved in modulating HSF2 activation in testis. Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity). | Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I. | 0.791 |
| HSF2BP | SYCP3 | ENSP00000291560 | ENSP00000376658 | Heat shock factor 2-binding protein; May be involved in modulating HSF2 activation in testis. Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity). | Synaptonemal complex protein 3; Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells (By similarity). Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity). Belongs to the XLR/SYCP3 family. | 0.445 |
| KRTAP10-9 | C19orf57 | ENSP00000381009 | ENSP00000254336 | Keratin-associated protein 10-9; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. | Uncharacterized protein C19orf57; Chromosome 19 open reading frame 57. | 0.463 |
| MEIOB | C19orf57 | ENSP00000314484 | ENSP00000254336 | Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity i [...] | Uncharacterized protein C19orf57; Chromosome 19 open reading frame 57. | 0.615 |
page 1 of 2