node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C22orf23 | C2CD6 | ENSP00000384667 | ENSP00000409937 | UPF0193 protein EVG1; Chromosome 22 open reading frame 23. | C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6. | 0.540 |
C22orf23 | GKAP1 | ENSP00000384667 | ENSP00000365550 | UPF0193 protein EVG1; Chromosome 22 open reading frame 23. | G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. | 0.507 |
C22orf23 | TSACC | ENSP00000384667 | ENSP00000357238 | UPF0193 protein EVG1; Chromosome 22 open reading frame 23. | TSSK6-activating co-chaperone protein; Co-chaperone that facilitates HSP-mediated activation of TSSK6; Belongs to the TSACC family. | 0.663 |
C2CD6 | C22orf23 | ENSP00000409937 | ENSP00000384667 | C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6. | UPF0193 protein EVG1; Chromosome 22 open reading frame 23. | 0.540 |
C2CD6 | C7orf61 | ENSP00000409937 | ENSP00000327732 | C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6. | Uncharacterized protein C7orf61; Chromosome 7 open reading frame 61. | 0.678 |
C2CD6 | CCDC62 | ENSP00000409937 | ENSP00000253079 | C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6. | Coiled-coil domain-containing protein 62; Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR. | 0.507 |
C2CD6 | EFCAB9 | ENSP00000409937 | ENSP00000381247 | C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6. | EF-hand calcium-binding domain-containing protein 9; pH-dependent Ca(2+) sensor required to activate the CatSper channel, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Associates with the CatSper complex via direct interaction with CATSPERZ, and senses intracellular Ca(2+). Together with CATSPERZ, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel. | 0.626 |
C2CD6 | FLACC1 | ENSP00000409937 | ENSP00000385098 | C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6. | Flagellum-associated coiled-coil domain-containing protein 1; Flagellum associated containing coiled-coil domains 1. | 0.517 |
C2CD6 | GKAP1 | ENSP00000409937 | ENSP00000365550 | C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6. | G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. | 0.480 |
C2CD6 | SPATA16 | ENSP00000409937 | ENSP00000341765 | C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6. | Spermatogenesis-associated protein 16; Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion. | 0.596 |
C2CD6 | TMEM237 | ENSP00000409937 | ENSP00000386264 | C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6. | Transmembrane protein 237; Component of the transition zone in primary cilia. Required for ciliogenesis; Belongs to the TMEM237 family. | 0.522 |
C2CD6 | TSACC | ENSP00000409937 | ENSP00000357238 | C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6. | TSSK6-activating co-chaperone protein; Co-chaperone that facilitates HSP-mediated activation of TSSK6; Belongs to the TSACC family. | 0.568 |
C2CD6 | ZPBP | ENSP00000409937 | ENSP00000046087 | C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6. | Zona pellucida-binding protein 1; Plays a role in acrosome compaction and sperm morphogenesis. Is implicated in sperm-oocyte interaction during fertilization (By similarity). | 0.488 |
C7orf61 | C2CD6 | ENSP00000327732 | ENSP00000409937 | Uncharacterized protein C7orf61; Chromosome 7 open reading frame 61. | C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6. | 0.678 |
C7orf61 | CCDC62 | ENSP00000327732 | ENSP00000253079 | Uncharacterized protein C7orf61; Chromosome 7 open reading frame 61. | Coiled-coil domain-containing protein 62; Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR. | 0.539 |
C7orf61 | SPATA16 | ENSP00000327732 | ENSP00000341765 | Uncharacterized protein C7orf61; Chromosome 7 open reading frame 61. | Spermatogenesis-associated protein 16; Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion. | 0.679 |
C7orf61 | ZPBP | ENSP00000327732 | ENSP00000046087 | Uncharacterized protein C7orf61; Chromosome 7 open reading frame 61. | Zona pellucida-binding protein 1; Plays a role in acrosome compaction and sperm morphogenesis. Is implicated in sperm-oocyte interaction during fertilization (By similarity). | 0.647 |
CCDC62 | C2CD6 | ENSP00000253079 | ENSP00000409937 | Coiled-coil domain-containing protein 62; Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR. | C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6. | 0.507 |
CCDC62 | C7orf61 | ENSP00000253079 | ENSP00000327732 | Coiled-coil domain-containing protein 62; Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR. | Uncharacterized protein C7orf61; Chromosome 7 open reading frame 61. | 0.539 |
CCDC62 | SPATA16 | ENSP00000253079 | ENSP00000341765 | Coiled-coil domain-containing protein 62; Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR. | Spermatogenesis-associated protein 16; Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion. | 0.581 |