node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C19orf73 | C2orf68 | ENSP00000386230 | ENSP00000304410 | Putative uncharacterized protein C19orf73; Chromosome 19 open reading frame 73. | UPF0561 protein C2orf68; Chromosome 2 open reading frame 68. | 0.571 |
C19orf73 | RASA4B | ENSP00000386230 | ENSP00000440982 | Putative uncharacterized protein C19orf73; Chromosome 19 open reading frame 73. | RAS p21 protein activator 4B. | 0.570 |
C2orf68 | C19orf73 | ENSP00000304410 | ENSP00000386230 | UPF0561 protein C2orf68; Chromosome 2 open reading frame 68. | Putative uncharacterized protein C19orf73; Chromosome 19 open reading frame 73. | 0.571 |
C2orf68 | DDHD2 | ENSP00000304410 | ENSP00000380352 | UPF0561 protein C2orf68; Chromosome 2 open reading frame 68. | Phospholipase DDHD2; Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3- phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane. | 0.456 |
C2orf68 | GNE | ENSP00000304410 | ENSP00000379839 | UPF0561 protein C2orf68; Chromosome 2 open reading frame 68. | Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells; In the C-terminal section; belongs to the ROK (NagC/XylR) family. | 0.589 |
C2orf68 | HDDC2 | ENSP00000304410 | ENSP00000381220 | UPF0561 protein C2orf68; Chromosome 2 open reading frame 68. | HD domain containing 2. | 0.447 |
C2orf68 | PIR | ENSP00000304410 | ENSP00000369786 | UPF0561 protein C2orf68; Chromosome 2 open reading frame 68. | Pirin; Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox- state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). Belongs to the pirin family. | 0.606 |
C2orf68 | PWWP2B | ENSP00000304410 | ENSP00000306324 | UPF0561 protein C2orf68; Chromosome 2 open reading frame 68. | PWWP domain containing 2B. | 0.473 |
C2orf68 | RASA4B | ENSP00000304410 | ENSP00000440982 | UPF0561 protein C2orf68; Chromosome 2 open reading frame 68. | RAS p21 protein activator 4B. | 0.479 |
C2orf68 | SH2D6 | ENSP00000304410 | ENSP00000498488 | UPF0561 protein C2orf68; Chromosome 2 open reading frame 68. | SH2 domain containing 6. | 0.480 |
C2orf68 | SMG6 | ENSP00000304410 | ENSP00000263073 | UPF0561 protein C2orf68; Chromosome 2 open reading frame 68. | Telomerase-binding protein EST1A; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER). | 0.469 |
C2orf68 | ZNF316 | ENSP00000304410 | ENSP00000477706 | UPF0561 protein C2orf68; Chromosome 2 open reading frame 68. | Zinc finger protein 316; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.480 |
DDHD2 | C2orf68 | ENSP00000380352 | ENSP00000304410 | Phospholipase DDHD2; Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3- phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane. | UPF0561 protein C2orf68; Chromosome 2 open reading frame 68. | 0.456 |
GNE | C2orf68 | ENSP00000379839 | ENSP00000304410 | Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells; In the C-terminal section; belongs to the ROK (NagC/XylR) family. | UPF0561 protein C2orf68; Chromosome 2 open reading frame 68. | 0.589 |
HDDC2 | C2orf68 | ENSP00000381220 | ENSP00000304410 | HD domain containing 2. | UPF0561 protein C2orf68; Chromosome 2 open reading frame 68. | 0.447 |
HDDC2 | ZNF316 | ENSP00000381220 | ENSP00000477706 | HD domain containing 2. | Zinc finger protein 316; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.461 |
PIR | C2orf68 | ENSP00000369786 | ENSP00000304410 | Pirin; Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox- state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). Belongs to the pirin family. | UPF0561 protein C2orf68; Chromosome 2 open reading frame 68. | 0.606 |
PWWP2B | C2orf68 | ENSP00000306324 | ENSP00000304410 | PWWP domain containing 2B. | UPF0561 protein C2orf68; Chromosome 2 open reading frame 68. | 0.473 |
RASA4B | C19orf73 | ENSP00000440982 | ENSP00000386230 | RAS p21 protein activator 4B. | Putative uncharacterized protein C19orf73; Chromosome 19 open reading frame 73. | 0.570 |
RASA4B | C2orf68 | ENSP00000440982 | ENSP00000304410 | RAS p21 protein activator 4B. | UPF0561 protein C2orf68; Chromosome 2 open reading frame 68. | 0.479 |