STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C2orf68UPF0561 protein C2orf68; Chromosome 2 open reading frame 68 (166 aa)    
Predicted Functional Partners:
C19orf73
Putative uncharacterized protein C19orf73; Chromosome 19 open reading frame 73
      
 0.681
ZNF316
Zinc finger protein 316; May be involved in transcriptional regulation; Zinc fingers C2H2-type
      
 0.671
HDDC2
Putative hydrolases of hd superfamily; HD domain containing 2; Belongs to the HDDC2 family
      
 0.651
METTL15
Probable methyltransferase-like protein 15; Probable S-adenosyl-L-methionine-dependent methyltransferase
      
 0.615
SH2D6
SH2 domain-containing protein 6; SH2 domain containing 6
      
 0.612
RASA4B
Ras GTPase-activating protein 4B; Pleckstrin homology domain containing; C2 and RasGAP domain containing
      
 0.529
NDOR1
NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins (By similarity). Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1; Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family
      
 0.528
TMEM150A
Transmembrane protein 150A; Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex. Acts as a regulator of phosphatidylinositol 4- phosphate (PtdIns(4)P) synthesis. May also play a role in fasting-induced catabolism (By similarity)
      
 0.517
RNF181
E3 ubiquitin-protein ligase RNF181; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates; Belongs to the RNF181 family
      
 0.499
TBKBP1
TANK-binding kinase 1-binding protein 1; Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity
      
 0.488
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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