node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CBWD1 | CBWD2 | ENSP00000366617 | ENSP00000259199 | COBW domain containing 1. | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | 0.929 |
CBWD1 | CBWD6 | ENSP00000366617 | ENSP00000366608 | COBW domain containing 1. | COBW domain containing 6; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | 0.626 |
CBWD1 | METAP1 | ENSP00000366617 | ENSP00000296411 | COBW domain containing 1. | Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle. | 0.738 |
CBWD1 | MRPL33 | ENSP00000366617 | ENSP00000296102 | COBW domain containing 1. | Mitochondrial ribosomal protein L33. | 0.489 |
CBWD1 | RPS29 | ENSP00000366617 | ENSP00000379339 | COBW domain containing 1. | Ribosomal protein S29. | 0.459 |
CBWD1 | SETD2 | ENSP00000366617 | ENSP00000386759 | COBW domain containing 1. | Histone-lysine N-methyltransferase SETD2; Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair [...] | 0.501 |
CBWD1 | TCERG1 | ENSP00000366617 | ENSP00000296702 | COBW domain containing 1. | Transcription elongation regulator 1; Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter. | 0.662 |
CBWD2 | CBWD1 | ENSP00000259199 | ENSP00000366617 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | COBW domain containing 1. | 0.929 |
CBWD2 | CBWD6 | ENSP00000259199 | ENSP00000366608 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | COBW domain containing 6; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | 0.828 |
CBWD2 | CCDC74B | ENSP00000259199 | ENSP00000308873 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | Coiled-coil domain containing 74B. | 0.541 |
CBWD2 | EGLN1 | ENSP00000259199 | ENSP00000355601 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | Egl nine homolog 1; Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is [...] | 0.559 |
CBWD2 | HSPA12A | ENSP00000259199 | ENSP00000489674 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | Heat shock 70 kDa protein 12A; Adapter protein for SORL1, but not SORT1. Delays SORL1 internalization and affects SORL1 subcellular localization. | 0.577 |
CBWD2 | METAP1 | ENSP00000259199 | ENSP00000296411 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle. | 0.843 |
CBWD2 | MRPL33 | ENSP00000259199 | ENSP00000296102 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | Mitochondrial ribosomal protein L33. | 0.518 |
CBWD2 | RPS29 | ENSP00000259199 | ENSP00000379339 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | Ribosomal protein S29. | 0.560 |
CBWD2 | SETD2 | ENSP00000259199 | ENSP00000386759 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | Histone-lysine N-methyltransferase SETD2; Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair [...] | 0.497 |
CBWD2 | TCERG1 | ENSP00000259199 | ENSP00000296702 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | Transcription elongation regulator 1; Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter. | 0.748 |
CBWD6 | CBWD1 | ENSP00000366608 | ENSP00000366617 | COBW domain containing 6; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | COBW domain containing 1. | 0.626 |
CBWD6 | CBWD2 | ENSP00000366608 | ENSP00000259199 | COBW domain containing 6; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | 0.828 |
CBWD6 | MRPL33 | ENSP00000366608 | ENSP00000296102 | COBW domain containing 6; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | Mitochondrial ribosomal protein L33. | 0.482 |