node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATIC | CNNM1 | ENSP00000236959 | ENSP00000349147 | Bifunctional purine biosynthesis protein PURH, N-terminally processed; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | 0.630 |
ATIC | GMPS | ENSP00000236959 | ENSP00000419851 | Bifunctional purine biosynthesis protein PURH, N-terminally processed; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | GMP synthase [glutamine-hydrolyzing]; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. | 0.921 |
CBS | CBSL | ENSP00000381231 | ENSP00000485527 | Cystathionine beta-synthase-like protein; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons. | Cystathionine beta-synthase like. | 0.900 |
CBS | CNNM1 | ENSP00000381231 | ENSP00000349147 | Cystathionine beta-synthase-like protein; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons. | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | 0.906 |
CBS | GMPS | ENSP00000381231 | ENSP00000419851 | Cystathionine beta-synthase-like protein; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons. | GMP synthase [glutamine-hydrolyzing]; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. | 0.526 |
CBS | SLC41A1 | ENSP00000381231 | ENSP00000356105 | Cystathionine beta-synthase-like protein; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons. | Solute carrier family 41 member 1; Acts as a magnesium transporter that is responsive to magnesium balance. | 0.426 |
CBSL | CBS | ENSP00000485527 | ENSP00000381231 | Cystathionine beta-synthase like. | Cystathionine beta-synthase-like protein; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons. | 0.900 |
CBSL | CNNM1 | ENSP00000485527 | ENSP00000349147 | Cystathionine beta-synthase like. | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | 0.912 |
CBSL | GMPS | ENSP00000485527 | ENSP00000419851 | Cystathionine beta-synthase like. | GMP synthase [glutamine-hydrolyzing]; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. | 0.513 |
CBSL | SLC41A1 | ENSP00000485527 | ENSP00000356105 | Cystathionine beta-synthase like. | Solute carrier family 41 member 1; Acts as a magnesium transporter that is responsive to magnesium balance. | 0.425 |
CNNM1 | ATIC | ENSP00000349147 | ENSP00000236959 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Bifunctional purine biosynthesis protein PURH, N-terminally processed; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | 0.630 |
CNNM1 | CBS | ENSP00000349147 | ENSP00000381231 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Cystathionine beta-synthase-like protein; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons. | 0.906 |
CNNM1 | CBSL | ENSP00000349147 | ENSP00000485527 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Cystathionine beta-synthase like. | 0.912 |
CNNM1 | COX11 | ENSP00000349147 | ENSP00000299335 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Cytochrome c oxidase assembly protein COX11, mitochondrial; Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. | 0.704 |
CNNM1 | GMPS | ENSP00000349147 | ENSP00000419851 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | GMP synthase [glutamine-hydrolyzing]; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. | 0.701 |
CNNM1 | HPSE2 | ENSP00000349147 | ENSP00000359583 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Inactive heparanase-2; Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro). | 0.655 |
CNNM1 | PTP4A1 | ENSP00000349147 | ENSP00000497588 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. | 0.734 |
CNNM1 | PTP4A2 | ENSP00000349147 | ENSP00000493688 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Protein tyrosine phosphatase type IVA 2; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. | 0.786 |
CNNM1 | SLC41A1 | ENSP00000349147 | ENSP00000356105 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Solute carrier family 41 member 1; Acts as a magnesium transporter that is responsive to magnesium balance. | 0.676 |
CNNM1 | TRPM6 | ENSP00000349147 | ENSP00000354006 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Transient receptor potential cation channel subfamily M member 6; Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region; In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM6 sub-subfamily. | 0.703 |