node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DUX4 | ETV1 | ENSP00000458065 | ENSP00000405327 | Double homeobox protein 4-like protein 2; May be involved in transcriptional regulation. | ETS translocation variant 1; Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'; Belongs to the ETS family. | 0.789 |
DUX4 | ETV5 | ENSP00000458065 | ENSP00000306894 | Double homeobox protein 4-like protein 2; May be involved in transcriptional regulation. | ETS translocation variant 5; Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'; Belongs to the ETS family. | 0.861 |
DUX4 | FRG1 | ENSP00000458065 | ENSP00000226798 | Double homeobox protein 4-like protein 2; May be involved in transcriptional regulation. | Protein FRG1; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B. Belongs to the FRG1 family. | 0.927 |
DUX4 | FRG2 | ENSP00000458065 | ENSP00000424015 | Double homeobox protein 4-like protein 2; May be involved in transcriptional regulation. | Protein FRG2; FSHD region gene 2. | 0.940 |
DUX4 | LEUTX | ENSP00000458065 | ENSP00000380053 | Double homeobox protein 4-like protein 2; May be involved in transcriptional regulation. | Leucine twenty homeobox. | 0.749 |
DUX4 | MYOD1 | ENSP00000458065 | ENSP00000250003 | Double homeobox protein 4-like protein 2; May be involved in transcriptional regulation. | Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). | 0.729 |
DUX4 | SMCHD1 | ENSP00000458065 | ENSP00000326603 | Double homeobox protein 4-like protein 2; May be involved in transcriptional regulation. | Structural maintenance of chromosomes flexible hinge domain-containing protein 1; Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (By similarity). Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments (By similarity). Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin. Recruited to inactivated chromosome X by Xist RNA and acts by mediating t [...] | 0.872 |
DUX4 | TRIM43 | ENSP00000458065 | ENSP00000272395 | Double homeobox protein 4-like protein 2; May be involved in transcriptional regulation. | Tripartite motif containing 43. | 0.776 |
DUX4 | ZNF384 | ENSP00000458065 | ENSP00000380019 | Double homeobox protein 4-like protein 2; May be involved in transcriptional regulation. | Zinc finger protein 384; Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1 (By similarity); Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.796 |
DUX4 | ZSCAN4 | ENSP00000458065 | ENSP00000321963 | Double homeobox protein 4-like protein 2; May be involved in transcriptional regulation. | Zinc finger and SCAN domain-containing protein 4; Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity). | 0.774 |
ETV1 | DUX4 | ENSP00000405327 | ENSP00000458065 | ETS translocation variant 1; Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'; Belongs to the ETS family. | Double homeobox protein 4-like protein 2; May be involved in transcriptional regulation. | 0.789 |
ETV5 | DUX4 | ENSP00000306894 | ENSP00000458065 | ETS translocation variant 5; Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'; Belongs to the ETS family. | Double homeobox protein 4-like protein 2; May be involved in transcriptional regulation. | 0.861 |
FRG1 | DUX4 | ENSP00000226798 | ENSP00000458065 | Protein FRG1; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B. Belongs to the FRG1 family. | Double homeobox protein 4-like protein 2; May be involved in transcriptional regulation. | 0.927 |
FRG1 | FRG2 | ENSP00000226798 | ENSP00000424015 | Protein FRG1; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B. Belongs to the FRG1 family. | Protein FRG2; FSHD region gene 2. | 0.987 |
FRG1 | MYOD1 | ENSP00000226798 | ENSP00000250003 | Protein FRG1; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B. Belongs to the FRG1 family. | Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). | 0.503 |
FRG1 | SMCHD1 | ENSP00000226798 | ENSP00000326603 | Protein FRG1; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B. Belongs to the FRG1 family. | Structural maintenance of chromosomes flexible hinge domain-containing protein 1; Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (By similarity). Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments (By similarity). Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin. Recruited to inactivated chromosome X by Xist RNA and acts by mediating t [...] | 0.495 |
FRG2 | DUX4 | ENSP00000424015 | ENSP00000458065 | Protein FRG2; FSHD region gene 2. | Double homeobox protein 4-like protein 2; May be involved in transcriptional regulation. | 0.940 |
FRG2 | FRG1 | ENSP00000424015 | ENSP00000226798 | Protein FRG2; FSHD region gene 2. | Protein FRG1; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B. Belongs to the FRG1 family. | 0.987 |
FRG2 | MYOD1 | ENSP00000424015 | ENSP00000250003 | Protein FRG2; FSHD region gene 2. | Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). | 0.528 |
FRG2 | SMCHD1 | ENSP00000424015 | ENSP00000326603 | Protein FRG2; FSHD region gene 2. | Structural maintenance of chromosomes flexible hinge domain-containing protein 1; Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (By similarity). Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments (By similarity). Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin. Recruited to inactivated chromosome X by Xist RNA and acts by mediating t [...] | 0.434 |