node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EVX2 | HOXD10 | ENSP00000312385 | ENSP00000249501 | Even-skipped homeobox 2; Belongs to the even-skipped homeobox family. | Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. | 0.653 |
EVX2 | HOXD11 | ENSP00000312385 | ENSP00000249504 | Even-skipped homeobox 2; Belongs to the even-skipped homeobox family. | Homeobox protein Hox-D11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. | 0.643 |
EVX2 | HOXD12 | ENSP00000312385 | ENSP00000385586 | Even-skipped homeobox 2; Belongs to the even-skipped homeobox family. | Homeobox protein Hox-D12; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. | 0.647 |
EVX2 | HOXD13 | ENSP00000312385 | ENSP00000376322 | Even-skipped homeobox 2; Belongs to the even-skipped homeobox family. | Homeobox protein Hox-D13; Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity). Belongs to the Abd-B homeobox family. | 0.565 |
EVX2 | HOXD9 | ENSP00000312385 | ENSP00000249499 | Even-skipped homeobox 2; Belongs to the even-skipped homeobox family. | Homeobox protein Hox-D9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. | 0.516 |
EVX2 | LHX1 | ENSP00000312385 | ENSP00000477829 | Even-skipped homeobox 2; Belongs to the even-skipped homeobox family. | LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. | 0.521 |
EVX2 | LNPK | ENSP00000312385 | ENSP00000440905 | Even-skipped homeobox 2; Belongs to the even-skipped homeobox family. | Endoplasmic reticulum junction formation protein lunapark; Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network. May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network. May be involved in limb development (By similarity). Is involved in central nervous system development. | 0.879 |
EVX2 | MTX2 | ENSP00000312385 | ENSP00000249442 | Even-skipped homeobox 2; Belongs to the even-skipped homeobox family. | Metaxin-2; Involved in transport of proteins into the mitochondrion. | 0.837 |
EVX2 | SHH | ENSP00000312385 | ENSP00000297261 | Even-skipped homeobox 2; Belongs to the even-skipped homeobox family. | Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.531 |
EVX2 | SPOP | ENSP00000312385 | ENSP00000377001 | Even-skipped homeobox 2; Belongs to the even-skipped homeobox family. | Speckle-type POZ protein; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING- [...] | 0.549 |
HOXD10 | EVX2 | ENSP00000249501 | ENSP00000312385 | Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. | Even-skipped homeobox 2; Belongs to the even-skipped homeobox family. | 0.653 |
HOXD10 | HOXD11 | ENSP00000249501 | ENSP00000249504 | Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. | Homeobox protein Hox-D11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. | 0.999 |
HOXD10 | HOXD12 | ENSP00000249501 | ENSP00000385586 | Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. | Homeobox protein Hox-D12; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. | 0.580 |
HOXD10 | HOXD13 | ENSP00000249501 | ENSP00000376322 | Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. | Homeobox protein Hox-D13; Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity). Belongs to the Abd-B homeobox family. | 0.808 |
HOXD10 | HOXD9 | ENSP00000249501 | ENSP00000249499 | Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. | Homeobox protein Hox-D9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. | 0.860 |
HOXD10 | SHH | ENSP00000249501 | ENSP00000297261 | Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. | Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.693 |
HOXD11 | EVX2 | ENSP00000249504 | ENSP00000312385 | Homeobox protein Hox-D11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. | Even-skipped homeobox 2; Belongs to the even-skipped homeobox family. | 0.643 |
HOXD11 | HOXD10 | ENSP00000249504 | ENSP00000249501 | Homeobox protein Hox-D11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. | Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. | 0.999 |
HOXD11 | HOXD13 | ENSP00000249504 | ENSP00000376322 | Homeobox protein Hox-D11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. | Homeobox protein Hox-D13; Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity). Belongs to the Abd-B homeobox family. | 0.788 |
HOXD11 | HOXD9 | ENSP00000249504 | ENSP00000249499 | Homeobox protein Hox-D11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. | Homeobox protein Hox-D9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. | 0.751 |