STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FAM241BProtein FAM241B; May play a role in lysosome homeostasis. Belongs to the FAM241 family. (121 aa)    
Predicted Functional Partners:
LRRC69
Leucine-rich repeat-containing protein 69; Leucine rich repeat containing 69.
      
 0.527
PRRT1
Proline rich transmembrane protein 1.
    
   0.518
TEX26
Testis-expressed protein 26; Testis expressed 26.
      
 0.506
PLSCR5
Phospholipid scramblase family member 5; Belongs to the phospholipid scramblase family.
      
 0.476
WLS
Protein wntless homolog; Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).
    
   0.474
FAM149B1
Protein FAM149B1; Family with sequence similarity 149 member B1.
      
 0.448
FAM160A2
FTS and Hook-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Belongs to the UPF0518 family.
      
 0.446
ARL6IP5
PRA1 family protein 3; Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity- dependent manner. May be involved in membrane traffic.
    
   0.435
TMEM170A
Transmembrane protein 170A; Acts as a regulator of endoplasmic reticulum (ER) and nuclear envelope (NE) morphogenesis. Affects the ratio between tubular ER and ER sheets by promoting sheet formation at the expense of tubules. Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins. Belongs to the TMEM170 family.
   
   0.429
TMEM208
Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
   
   0.423
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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