node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHERP | FRA10AC1 | ENSP00000439856 | ENSP00000360488 | Calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation. | Protein FRA10AC1; FRA10A associated CGG repeat 1. | 0.773 |
CHERP | SF3B2 | ENSP00000439856 | ENSP00000318861 | Calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation. | Splicing factor 3B subunit 2; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. | 0.715 |
CWC27 | FRA10AC1 | ENSP00000370460 | ENSP00000360488 | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. | Protein FRA10AC1; FRA10A associated CGG repeat 1. | 0.844 |
CWC27 | IK | ENSP00000370460 | ENSP00000396301 | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. | Protein Red; Involved in pre-mRNA splicing as a component of the spliceosome. Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression. Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint. Required for normal accumulation of SMU1. | 0.925 |
CWC27 | SF3B2 | ENSP00000370460 | ENSP00000318861 | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. | Splicing factor 3B subunit 2; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. | 0.993 |
ESS2 | FRA10AC1 | ENSP00000252137 | ENSP00000360488 | Splicing factor ESS-2 homolog; May be involved in pre-mRNA splicing. | Protein FRA10AC1; FRA10A associated CGG repeat 1. | 0.831 |
ESS2 | LENG1 | ENSP00000252137 | ENSP00000222224 | Splicing factor ESS-2 homolog; May be involved in pre-mRNA splicing. | Leukocyte receptor cluster member 1. | 0.605 |
FRA10AC1 | CHERP | ENSP00000360488 | ENSP00000439856 | Protein FRA10AC1; FRA10A associated CGG repeat 1. | Calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation. | 0.773 |
FRA10AC1 | CWC27 | ENSP00000360488 | ENSP00000370460 | Protein FRA10AC1; FRA10A associated CGG repeat 1. | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. | 0.844 |
FRA10AC1 | ESS2 | ENSP00000360488 | ENSP00000252137 | Protein FRA10AC1; FRA10A associated CGG repeat 1. | Splicing factor ESS-2 homolog; May be involved in pre-mRNA splicing. | 0.831 |
FRA10AC1 | IK | ENSP00000360488 | ENSP00000396301 | Protein FRA10AC1; FRA10A associated CGG repeat 1. | Protein Red; Involved in pre-mRNA splicing as a component of the spliceosome. Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression. Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint. Required for normal accumulation of SMU1. | 0.714 |
FRA10AC1 | LENG1 | ENSP00000360488 | ENSP00000222224 | Protein FRA10AC1; FRA10A associated CGG repeat 1. | Leukocyte receptor cluster member 1. | 0.665 |
FRA10AC1 | LGI1 | ENSP00000360488 | ENSP00000360472 | Protein FRA10AC1; FRA10A associated CGG repeat 1. | Leucine-rich glioma-inactivated protein 1; Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival. | 0.764 |
FRA10AC1 | PDE6C | ENSP00000360488 | ENSP00000360502 | Protein FRA10AC1; FRA10A associated CGG repeat 1. | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP. | 0.826 |
FRA10AC1 | SF3B2 | ENSP00000360488 | ENSP00000318861 | Protein FRA10AC1; FRA10A associated CGG repeat 1. | Splicing factor 3B subunit 2; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. | 0.739 |
FRA10AC1 | TMEM185A | ENSP00000360488 | ENSP00000471932 | Protein FRA10AC1; FRA10A associated CGG repeat 1. | Transmembrane protein 185A; Belongs to the TMEM185 family. | 0.658 |
FRA10AC1 | ZNF32 | ENSP00000360488 | ENSP00000379143 | Protein FRA10AC1; FRA10A associated CGG repeat 1. | Zinc finger protein 32; May be involved in transcriptional regulation. | 0.913 |
IK | CWC27 | ENSP00000396301 | ENSP00000370460 | Protein Red; Involved in pre-mRNA splicing as a component of the spliceosome. Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression. Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint. Required for normal accumulation of SMU1. | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. | 0.925 |
IK | FRA10AC1 | ENSP00000396301 | ENSP00000360488 | Protein Red; Involved in pre-mRNA splicing as a component of the spliceosome. Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression. Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint. Required for normal accumulation of SMU1. | Protein FRA10AC1; FRA10A associated CGG repeat 1. | 0.714 |
IK | SF3B2 | ENSP00000396301 | ENSP00000318861 | Protein Red; Involved in pre-mRNA splicing as a component of the spliceosome. Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression. Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint. Required for normal accumulation of SMU1. | Splicing factor 3B subunit 2; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. | 0.924 |