node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABAT | GAD1 | ENSP00000379845 | ENSP00000350928 | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L-beta- aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Glutamate decarboxylase 1; Catalyzes the production of GABA. | 0.975 |
ABAT | GAD2 | ENSP00000379845 | ENSP00000365437 | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L-beta- aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Glutamate decarboxylase 2; Catalyzes the production of GABA. | 0.976 |
ABAT | GLUD1 | ENSP00000379845 | ENSP00000277865 | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L-beta- aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). | 0.729 |
ABAT | GLUD2 | ENSP00000379845 | ENSP00000327589 | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L-beta- aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Glutamate dehydrogenase 2, mitochondrial; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission. | 0.743 |
ABAT | GLUL | ENSP00000379845 | ENSP00000307900 | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L-beta- aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine. Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane locali [...] | 0.562 |
CDO1 | GAD1 | ENSP00000250535 | ENSP00000350928 | Cysteine dioxygenase type 1; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. | Glutamate decarboxylase 1; Catalyzes the production of GABA. | 0.932 |
CDO1 | GAD2 | ENSP00000250535 | ENSP00000365437 | Cysteine dioxygenase type 1; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. | Glutamate decarboxylase 2; Catalyzes the production of GABA. | 0.931 |
GAD1 | ABAT | ENSP00000350928 | ENSP00000379845 | Glutamate decarboxylase 1; Catalyzes the production of GABA. | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L-beta- aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.975 |
GAD1 | CDO1 | ENSP00000350928 | ENSP00000250535 | Glutamate decarboxylase 1; Catalyzes the production of GABA. | Cysteine dioxygenase type 1; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. | 0.932 |
GAD1 | GAD2 | ENSP00000350928 | ENSP00000365437 | Glutamate decarboxylase 1; Catalyzes the production of GABA. | Glutamate decarboxylase 2; Catalyzes the production of GABA. | 0.968 |
GAD1 | GLS | ENSP00000350928 | ENSP00000317379 | Glutamate decarboxylase 1; Catalyzes the production of GABA. | Glutaminase kidney isoform, mitochondrial 65 kDa chain; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain ; Belongs to the glutaminase family. | 0.948 |
GAD1 | GLS2 | ENSP00000350928 | ENSP00000310447 | Glutamate decarboxylase 1; Catalyzes the production of GABA. | Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. | 0.950 |
GAD1 | GLUD1 | ENSP00000350928 | ENSP00000277865 | Glutamate decarboxylase 1; Catalyzes the production of GABA. | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). | 0.953 |
GAD1 | GLUD2 | ENSP00000350928 | ENSP00000327589 | Glutamate decarboxylase 1; Catalyzes the production of GABA. | Glutamate dehydrogenase 2, mitochondrial; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission. | 0.954 |
GAD1 | GLUL | ENSP00000350928 | ENSP00000307900 | Glutamate decarboxylase 1; Catalyzes the production of GABA. | Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine. Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane locali [...] | 0.953 |
GAD1 | PTPRN | ENSP00000350928 | ENSP00000295718 | Glutamate decarboxylase 1; Catalyzes the production of GABA. | Receptor-type tyrosine-protein phosphatase-like N; Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets (By similarity). Required for the accumulation of normal levels of insulin- containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (By similarity). In females, but not in males, required for normal accumulatio [...] | 0.535 |
GAD1 | SLC32A1 | ENSP00000350928 | ENSP00000217420 | Glutamate decarboxylase 1; Catalyzes the production of GABA. | Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles. | 0.977 |
GAD2 | ABAT | ENSP00000365437 | ENSP00000379845 | Glutamate decarboxylase 2; Catalyzes the production of GABA. | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L-beta- aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.976 |
GAD2 | CDO1 | ENSP00000365437 | ENSP00000250535 | Glutamate decarboxylase 2; Catalyzes the production of GABA. | Cysteine dioxygenase type 1; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. | 0.931 |
GAD2 | GAD1 | ENSP00000365437 | ENSP00000350928 | Glutamate decarboxylase 2; Catalyzes the production of GABA. | Glutamate decarboxylase 1; Catalyzes the production of GABA. | 0.968 |