node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANTKMT | HAGHL | ENSP00000454380 | ENSP00000374353 | Adenine nucleotide translocase lysine N-methyltransferase; Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration. Probably also trimethylates ANT1/SLC25A4. | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds. | 0.522 |
CCDC78 | HAGHL | ENSP00000293889 | ENSP00000374353 | Coiled-coil domain-containing protein 78; Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome. | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds. | 0.461 |
CSNK2A2 | HAGHL | ENSP00000262506 | ENSP00000374353 | Casein kinase II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoin [...] | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds. | 0.601 |
GLO1 | GLOD4 | ENSP00000362463 | ENSP00000301329 | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis. | Glyoxalase domain containing 4. | 0.601 |
GLO1 | HAGHL | ENSP00000362463 | ENSP00000374353 | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis. | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds. | 0.641 |
GLO1 | LACTB2 | ENSP00000362463 | ENSP00000276590 | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis. | Endoribonuclease LACTB2; Endoribonuclease; cleaves preferentially 3' to purine- pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double- stranded RNA or DNA. Required for normal mitochondrial function and cell viability; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | 0.459 |
GLO1 | MBLAC2 | ENSP00000362463 | ENSP00000314776 | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis. | Metallo-beta-lactamase domain containing 2; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | 0.411 |
GLOD4 | GLO1 | ENSP00000301329 | ENSP00000362463 | Glyoxalase domain containing 4. | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis. | 0.601 |
GLOD4 | HAGHL | ENSP00000301329 | ENSP00000374353 | Glyoxalase domain containing 4. | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds. | 0.500 |
GLOD4 | LACTB2 | ENSP00000301329 | ENSP00000276590 | Glyoxalase domain containing 4. | Endoribonuclease LACTB2; Endoribonuclease; cleaves preferentially 3' to purine- pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double- stranded RNA or DNA. Required for normal mitochondrial function and cell viability; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | 0.468 |
GLOD4 | MBLAC2 | ENSP00000301329 | ENSP00000314776 | Glyoxalase domain containing 4. | Metallo-beta-lactamase domain containing 2; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | 0.466 |
HAGHL | ANTKMT | ENSP00000374353 | ENSP00000454380 | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds. | Adenine nucleotide translocase lysine N-methyltransferase; Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration. Probably also trimethylates ANT1/SLC25A4. | 0.522 |
HAGHL | CCDC78 | ENSP00000374353 | ENSP00000293889 | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds. | Coiled-coil domain-containing protein 78; Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome. | 0.461 |
HAGHL | CSNK2A2 | ENSP00000374353 | ENSP00000262506 | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds. | Casein kinase II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoin [...] | 0.601 |
HAGHL | GLO1 | ENSP00000374353 | ENSP00000362463 | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds. | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis. | 0.641 |
HAGHL | GLOD4 | ENSP00000374353 | ENSP00000301329 | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds. | Glyoxalase domain containing 4. | 0.500 |
HAGHL | LACTB2 | ENSP00000374353 | ENSP00000276590 | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds. | Endoribonuclease LACTB2; Endoribonuclease; cleaves preferentially 3' to purine- pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double- stranded RNA or DNA. Required for normal mitochondrial function and cell viability; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | 0.544 |
HAGHL | MBLAC1 | ENSP00000374353 | ENSP00000381150 | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds. | Metallo-beta-lactamase domain containing 1. | 0.515 |
HAGHL | MBLAC2 | ENSP00000374353 | ENSP00000314776 | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds. | Metallo-beta-lactamase domain containing 2; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | 0.507 |
HAGHL | MKRN2 | ENSP00000374353 | ENSP00000170447 | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds. | Probable E3 ubiquitin-protein ligase makorin-2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. | 0.508 |