node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CSDE1 | HID1 | ENSP00000481762 | ENSP00000413520 | Cold shock domain-containing protein E1; RNA-binding protein. Required for internal initiation of translation of human rhinovirus RNA. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. | Protein HID1; May play an important role in the development of cancers in a broad range of tissues. | 0.598 |
CYP4B1 | HID1 | ENSP00000360991 | ENSP00000413520 | Cytochrome P450 4B1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | Protein HID1; May play an important role in the development of cancers in a broad range of tissues. | 0.493 |
DYM | HID1 | ENSP00000269445 | ENSP00000413520 | Dymeclin; Necessary for correct organization of Golgi apparatus. Involved in bone development; Belongs to the dymeclin family. | Protein HID1; May play an important role in the development of cancers in a broad range of tissues. | 0.603 |
GLE1 | HID1 | ENSP00000308622 | ENSP00000413520 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC). | Protein HID1; May play an important role in the development of cancers in a broad range of tissues. | 0.609 |
GLE1 | NUP155 | ENSP00000308622 | ENSP00000231498 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC). | Nuclear pore complex protein Nup155; Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. | 0.988 |
GLE1 | NUP214 | ENSP00000308622 | ENSP00000352400 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC). | Nuclear pore complex protein Nup214; Has a critical role in nucleocytoplasmic transport. May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. | 0.998 |
GLE1 | NUP54 | ENSP00000308622 | ENSP00000264883 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC). | Nucleoporin p54; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. | 0.924 |
GPD1L | HID1 | ENSP00000282541 | ENSP00000413520 | Glycerol-3-phosphate dehydrogenase 1-like protein; Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3- phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | Protein HID1; May play an important role in the development of cancers in a broad range of tissues. | 0.520 |
HID1 | CSDE1 | ENSP00000413520 | ENSP00000481762 | Protein HID1; May play an important role in the development of cancers in a broad range of tissues. | Cold shock domain-containing protein E1; RNA-binding protein. Required for internal initiation of translation of human rhinovirus RNA. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. | 0.598 |
HID1 | CYP4B1 | ENSP00000413520 | ENSP00000360991 | Protein HID1; May play an important role in the development of cancers in a broad range of tissues. | Cytochrome P450 4B1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.493 |
HID1 | DYM | ENSP00000413520 | ENSP00000269445 | Protein HID1; May play an important role in the development of cancers in a broad range of tissues. | Dymeclin; Necessary for correct organization of Golgi apparatus. Involved in bone development; Belongs to the dymeclin family. | 0.603 |
HID1 | GLE1 | ENSP00000413520 | ENSP00000308622 | Protein HID1; May play an important role in the development of cancers in a broad range of tissues. | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC). | 0.609 |
HID1 | GPD1L | ENSP00000413520 | ENSP00000282541 | Protein HID1; May play an important role in the development of cancers in a broad range of tissues. | Glycerol-3-phosphate dehydrogenase 1-like protein; Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3- phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | 0.520 |
HID1 | NUP155 | ENSP00000413520 | ENSP00000231498 | Protein HID1; May play an important role in the development of cancers in a broad range of tissues. | Nuclear pore complex protein Nup155; Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. | 0.575 |
HID1 | NUP214 | ENSP00000413520 | ENSP00000352400 | Protein HID1; May play an important role in the development of cancers in a broad range of tissues. | Nuclear pore complex protein Nup214; Has a critical role in nucleocytoplasmic transport. May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. | 0.494 |
HID1 | NUP54 | ENSP00000413520 | ENSP00000264883 | Protein HID1; May play an important role in the development of cancers in a broad range of tissues. | Nucleoporin p54; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. | 0.526 |
HID1 | USP40 | ENSP00000413520 | ENSP00000415434 | Protein HID1; May play an important role in the development of cancers in a broad range of tissues. | Ubiquitin carboxyl-terminal hydrolase 40; May be catalytically inactive; Belongs to the peptidase C19 family. | 0.620 |
HID1 | USP7 | ENSP00000413520 | ENSP00000343535 | Protein HID1; May play an important role in the development of cancers in a broad range of tissues. | Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the p [...] | 0.649 |
NUP155 | GLE1 | ENSP00000231498 | ENSP00000308622 | Nuclear pore complex protein Nup155; Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC). | 0.988 |
NUP155 | HID1 | ENSP00000231498 | ENSP00000413520 | Nuclear pore complex protein Nup155; Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. | Protein HID1; May play an important role in the development of cancers in a broad range of tissues. | 0.575 |