node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DIRC1 | HSPB2 | ENSP00000307860 | ENSP00000302476 | Disrupted in renal carcinoma 1. | Heat shock protein beta-2; May regulate the kinase DMPK. | 0.424 |
DIRC1 | HSPBAP1 | ENSP00000307860 | ENSP00000302562 | Disrupted in renal carcinoma 1. | HSPB1-associated protein 1; May play a role in cellular stress response. | 0.638 |
DIRC1 | LRIG1 | ENSP00000307860 | ENSP00000273261 | Disrupted in renal carcinoma 1. | Leucine-rich repeats and immunoglobulin-like domains protein 1; Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. | 0.649 |
DIRC1 | SLC49A4 | ENSP00000307860 | ENSP00000261038 | Disrupted in renal carcinoma 1. | Solute carrier family 49 member 4; Electrogenic metabolite transporter. Belongs to the major facilitator superfamily. | 0.697 |
HSPB1 | HSPBAP1 | ENSP00000248553 | ENSP00000302562 | Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. | HSPB1-associated protein 1; May play a role in cellular stress response. | 0.911 |
HSPB2 | DIRC1 | ENSP00000302476 | ENSP00000307860 | Heat shock protein beta-2; May regulate the kinase DMPK. | Disrupted in renal carcinoma 1. | 0.424 |
HSPB2 | HSPB3 | ENSP00000302476 | ENSP00000303394 | Heat shock protein beta-2; May regulate the kinase DMPK. | Heat shock protein beta-3; Inhibitor of actin polymerization. | 0.959 |
HSPB2 | HSPBAP1 | ENSP00000302476 | ENSP00000302562 | Heat shock protein beta-2; May regulate the kinase DMPK. | HSPB1-associated protein 1; May play a role in cellular stress response. | 0.882 |
HSPB2 | LRIG1 | ENSP00000302476 | ENSP00000273261 | Heat shock protein beta-2; May regulate the kinase DMPK. | Leucine-rich repeats and immunoglobulin-like domains protein 1; Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. | 0.425 |
HSPB2 | SLC49A4 | ENSP00000302476 | ENSP00000261038 | Heat shock protein beta-2; May regulate the kinase DMPK. | Solute carrier family 49 member 4; Electrogenic metabolite transporter. Belongs to the major facilitator superfamily. | 0.404 |
HSPB3 | HSPB2 | ENSP00000303394 | ENSP00000302476 | Heat shock protein beta-3; Inhibitor of actin polymerization. | Heat shock protein beta-2; May regulate the kinase DMPK. | 0.959 |
HSPB3 | HSPBAP1 | ENSP00000303394 | ENSP00000302562 | Heat shock protein beta-3; Inhibitor of actin polymerization. | HSPB1-associated protein 1; May play a role in cellular stress response. | 0.856 |
HSPBAP1 | DIRC1 | ENSP00000302562 | ENSP00000307860 | HSPB1-associated protein 1; May play a role in cellular stress response. | Disrupted in renal carcinoma 1. | 0.638 |
HSPBAP1 | HSPB1 | ENSP00000302562 | ENSP00000248553 | HSPB1-associated protein 1; May play a role in cellular stress response. | Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. | 0.911 |
HSPBAP1 | HSPB2 | ENSP00000302562 | ENSP00000302476 | HSPB1-associated protein 1; May play a role in cellular stress response. | Heat shock protein beta-2; May regulate the kinase DMPK. | 0.882 |
HSPBAP1 | HSPB3 | ENSP00000302562 | ENSP00000303394 | HSPB1-associated protein 1; May play a role in cellular stress response. | Heat shock protein beta-3; Inhibitor of actin polymerization. | 0.856 |
HSPBAP1 | JMJD4 | ENSP00000302562 | ENSP00000355720 | HSPB1-associated protein 1; May play a role in cellular stress response. | 2-oxoglutarate and iron-dependent oxygenase JMJD4; Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1. | 0.706 |
HSPBAP1 | JMJD7-PLA2G4B | ENSP00000302562 | ENSP00000371886 | HSPB1-associated protein 1; May play a role in cellular stress response. | Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7; JMJD7-PLA2G4B readthrough. | 0.517 |
HSPBAP1 | LRIG1 | ENSP00000302562 | ENSP00000273261 | HSPB1-associated protein 1; May play a role in cellular stress response. | Leucine-rich repeats and immunoglobulin-like domains protein 1; Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. | 0.588 |
HSPBAP1 | RIOX1 | ENSP00000302562 | ENSP00000477507 | HSPB1-associated protein 1; May play a role in cellular stress response. | Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys- 4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His- 216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OS [...] | 0.681 |