node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCL11A | KLHDC8B | ENSP00000496168 | ENSP00000327468 | B-cell lymphoma/leukemia 11A; Transcription factor associated with the BAF SWI/SNF chromatin remodeling complex (By similarity). Repressor of fetal hemoglobin (HbF) level. Involved in brain development. May play a role in hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1 (By similarity). | Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. | 0.648 |
CBFA2T3 | KLHDC8B | ENSP00000268679 | ENSP00000327468 | Protein CBFA2T3; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway. Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulatin [...] | Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. | 0.652 |
FAM133A | KLHDC8B | ENSP00000318974 | ENSP00000327468 | Protein FAM133A; Family with sequence similarity 133 member A. | Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. | 0.536 |
KBTBD12 | KLHDC8B | ENSP00000385957 | ENSP00000327468 | Kelch repeat and BTB domain containing 12. | Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. | 0.583 |
KBTBD12 | PRR35 | ENSP00000385957 | ENSP00000386499 | Kelch repeat and BTB domain containing 12. | Proline-rich protein 35; Proline rich 35. | 0.676 |
KBTBD12 | RRP36 | ENSP00000385957 | ENSP00000244496 | Kelch repeat and BTB domain containing 12. | Ribosomal RNA processing protein 36 homolog; Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA. Belongs to the RRP36 family. | 0.589 |
KBTBD12 | SIPA1L2 | ENSP00000385957 | ENSP00000355589 | Kelch repeat and BTB domain containing 12. | Signal-induced proliferation-associated 1-like protein 2; Signal induced proliferation associated 1 like 2. | 0.523 |
KBTBD12 | SPATA48 | ENSP00000385957 | ENSP00000297001 | Kelch repeat and BTB domain containing 12. | Spermatogenesis-associated protein 48; Spermatogenesis associated 48. | 0.554 |
KBTBD12 | TRAPPC6B | ENSP00000385957 | ENSP00000330289 | Kelch repeat and BTB domain containing 12. | Trafficking protein particle complex subunit 6B; Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic. Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (Probable). | 0.539 |
KLHDC8B | BCL11A | ENSP00000327468 | ENSP00000496168 | Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. | B-cell lymphoma/leukemia 11A; Transcription factor associated with the BAF SWI/SNF chromatin remodeling complex (By similarity). Repressor of fetal hemoglobin (HbF) level. Involved in brain development. May play a role in hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1 (By similarity). | 0.648 |
KLHDC8B | CBFA2T3 | ENSP00000327468 | ENSP00000268679 | Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. | Protein CBFA2T3; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway. Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulatin [...] | 0.652 |
KLHDC8B | FAM133A | ENSP00000327468 | ENSP00000318974 | Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. | Protein FAM133A; Family with sequence similarity 133 member A. | 0.536 |
KLHDC8B | KBTBD12 | ENSP00000327468 | ENSP00000385957 | Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. | Kelch repeat and BTB domain containing 12. | 0.583 |
KLHDC8B | PRR35 | ENSP00000327468 | ENSP00000386499 | Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. | Proline-rich protein 35; Proline rich 35. | 0.596 |
KLHDC8B | RRP36 | ENSP00000327468 | ENSP00000244496 | Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. | Ribosomal RNA processing protein 36 homolog; Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA. Belongs to the RRP36 family. | 0.532 |
KLHDC8B | SIPA1L2 | ENSP00000327468 | ENSP00000355589 | Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. | Signal-induced proliferation-associated 1-like protein 2; Signal induced proliferation associated 1 like 2. | 0.497 |
KLHDC8B | SPATA48 | ENSP00000327468 | ENSP00000297001 | Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. | Spermatogenesis-associated protein 48; Spermatogenesis associated 48. | 0.516 |
KLHDC8B | TIGD3 | ENSP00000327468 | ENSP00000308354 | Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. | Tigger transposable element derived 3. | 0.502 |
KLHDC8B | TRAPPC6B | ENSP00000327468 | ENSP00000330289 | Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. | Trafficking protein particle complex subunit 6B; Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic. Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (Probable). | 0.522 |
PRR35 | KBTBD12 | ENSP00000386499 | ENSP00000385957 | Proline-rich protein 35; Proline rich 35. | Kelch repeat and BTB domain containing 12. | 0.676 |