| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKS1A | FAM180A | ENSP00000353518 | ENSP00000342336 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). | Protein FAM180A; Family with sequence similarity 180 member A. | 0.514 |
| ANKS1A | GCC2 | ENSP00000353518 | ENSP00000307939 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2. | 0.452 |
| ANKS1A | KLHL35 | ENSP00000353518 | ENSP00000438526 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). | Kelch-like protein 35; Kelch like family member 35. | 0.516 |
| ANKS1A | PI15 | ENSP00000353518 | ENSP00000260113 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). | Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin. May play a role in facial patterning during embryonic development (By similarity). Belongs to the CRISP family. | 0.467 |
| ANKS1A | SCUBE3 | ENSP00000353518 | ENSP00000274938 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). | Signal peptide, CUB and EGF-like domain-containing protein 3; Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression. | 0.580 |
| ANKS1A | TCP11 | ENSP00000353518 | ENSP00000501201 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). | T-complex protein 11 homolog; Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization- promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway. Belongs to the TCP11 family. | 0.629 |
| CCDC8 | KLHL35 | ENSP00000303158 | ENSP00000438526 | Coiled-coil domain-containing protein 8; Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Required for localization of CUL7 to the centrosome. | Kelch-like protein 35; Kelch like family member 35. | 0.483 |
| CCDC8 | ZSCAN18 | ENSP00000303158 | ENSP00000470123 | Coiled-coil domain-containing protein 8; Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Required for localization of CUL7 to the centrosome. | Zinc finger and SCAN domain-containing protein 18; May be involved in transcriptional regulation. | 0.434 |
| CORO6 | KLHL35 | ENSP00000344562 | ENSP00000438526 | Coronin-6; Coronin 6. | Kelch-like protein 35; Kelch like family member 35. | 0.537 |
| CORO6 | SCUBE3 | ENSP00000344562 | ENSP00000274938 | Coronin-6; Coronin 6. | Signal peptide, CUB and EGF-like domain-containing protein 3; Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression. | 0.422 |
| DLEU7 | KLHL35 | ENSP00000427177 | ENSP00000438526 | Leukemia-associated protein 7; Deleted in lymphocytic leukemia 7. | Kelch-like protein 35; Kelch like family member 35. | 0.470 |
| FAM180A | ANKS1A | ENSP00000342336 | ENSP00000353518 | Protein FAM180A; Family with sequence similarity 180 member A. | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). | 0.514 |
| FAM180A | GCC2 | ENSP00000342336 | ENSP00000307939 | Protein FAM180A; Family with sequence similarity 180 member A. | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2. | 0.505 |
| FAM180A | KLHL35 | ENSP00000342336 | ENSP00000438526 | Protein FAM180A; Family with sequence similarity 180 member A. | Kelch-like protein 35; Kelch like family member 35. | 0.485 |
| FAM180A | PI15 | ENSP00000342336 | ENSP00000260113 | Protein FAM180A; Family with sequence similarity 180 member A. | Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin. May play a role in facial patterning during embryonic development (By similarity). Belongs to the CRISP family. | 0.566 |
| FAM180A | TCP11 | ENSP00000342336 | ENSP00000501201 | Protein FAM180A; Family with sequence similarity 180 member A. | T-complex protein 11 homolog; Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization- promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway. Belongs to the TCP11 family. | 0.473 |
| GCC2 | ANKS1A | ENSP00000307939 | ENSP00000353518 | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2. | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). | 0.452 |
| GCC2 | FAM180A | ENSP00000307939 | ENSP00000342336 | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2. | Protein FAM180A; Family with sequence similarity 180 member A. | 0.505 |
| GCC2 | KLHL35 | ENSP00000307939 | ENSP00000438526 | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2. | Kelch-like protein 35; Kelch like family member 35. | 0.495 |
| GCC2 | PI15 | ENSP00000307939 | ENSP00000260113 | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2. | Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin. May play a role in facial patterning during embryonic development (By similarity). Belongs to the CRISP family. | 0.481 |