node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADGRL1 | ISLR | ENSP00000340688 | ENSP00000249842 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity). | Immunoglobulin superfamily containing leucine rich repeat. | 0.515 |
ADGRL1 | LRRC40 | ENSP00000340688 | ENSP00000359990 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity). | Leucine-rich repeat-containing protein 40; Leucine rich repeat containing 40. | 0.514 |
ADGRL1 | LUM | ENSP00000340688 | ENSP00000266718 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity). | Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | 0.514 |
CNPY3 | GML | ENSP00000361926 | ENSP00000220940 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity). Belongs to the canopy family. | Glycosyl-phosphatidylinositol-anchored molecule-like protein; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. | 0.481 |
CNPY3 | LRRC40 | ENSP00000361926 | ENSP00000359990 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity). Belongs to the canopy family. | Leucine-rich repeat-containing protein 40; Leucine rich repeat containing 40. | 0.818 |
CNPY3 | TUBB8 | ENSP00000361926 | ENSP00000456206 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity). Belongs to the canopy family. | Tubulin beta-8 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). TUBB8 has a key role in meiotic spindle assembly and oocyte maturation ; Belongs to the tubulin family. | 0.469 |
GML | CNPY3 | ENSP00000220940 | ENSP00000361926 | Glycosyl-phosphatidylinositol-anchored molecule-like protein; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity). Belongs to the canopy family. | 0.481 |
GML | LRRC40 | ENSP00000220940 | ENSP00000359990 | Glycosyl-phosphatidylinositol-anchored molecule-like protein; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. | Leucine-rich repeat-containing protein 40; Leucine rich repeat containing 40. | 0.609 |
ISLR | ADGRL1 | ENSP00000249842 | ENSP00000340688 | Immunoglobulin superfamily containing leucine rich repeat. | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity). | 0.515 |
ISLR | LRRC40 | ENSP00000249842 | ENSP00000359990 | Immunoglobulin superfamily containing leucine rich repeat. | Leucine-rich repeat-containing protein 40; Leucine rich repeat containing 40. | 0.515 |
ISLR | LUM | ENSP00000249842 | ENSP00000266718 | Immunoglobulin superfamily containing leucine rich repeat. | Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | 0.460 |
ISLR | TUBB8 | ENSP00000249842 | ENSP00000456206 | Immunoglobulin superfamily containing leucine rich repeat. | Tubulin beta-8 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). TUBB8 has a key role in meiotic spindle assembly and oocyte maturation ; Belongs to the tubulin family. | 0.582 |
KCTD3 | LRRC40 | ENSP00000259154 | ENSP00000359990 | BTB/POZ domain-containing protein KCTD3; Accessory subunit of potassium/sodium hyperpolarization- activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics; Belongs to the KCTD3 family. | Leucine-rich repeat-containing protein 40; Leucine rich repeat containing 40. | 0.741 |
KCTD3 | MRI1 | ENSP00000259154 | ENSP00000040663 | BTB/POZ domain-containing protein KCTD3; Accessory subunit of potassium/sodium hyperpolarization- activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics; Belongs to the KCTD3 family. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover. | 0.619 |
LRRC40 | ADGRL1 | ENSP00000359990 | ENSP00000340688 | Leucine-rich repeat-containing protein 40; Leucine rich repeat containing 40. | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity). | 0.514 |
LRRC40 | CNPY3 | ENSP00000359990 | ENSP00000361926 | Leucine-rich repeat-containing protein 40; Leucine rich repeat containing 40. | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity). Belongs to the canopy family. | 0.818 |
LRRC40 | GML | ENSP00000359990 | ENSP00000220940 | Leucine-rich repeat-containing protein 40; Leucine rich repeat containing 40. | Glycosyl-phosphatidylinositol-anchored molecule-like protein; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. | 0.609 |
LRRC40 | ISLR | ENSP00000359990 | ENSP00000249842 | Leucine-rich repeat-containing protein 40; Leucine rich repeat containing 40. | Immunoglobulin superfamily containing leucine rich repeat. | 0.515 |
LRRC40 | KCTD3 | ENSP00000359990 | ENSP00000259154 | Leucine-rich repeat-containing protein 40; Leucine rich repeat containing 40. | BTB/POZ domain-containing protein KCTD3; Accessory subunit of potassium/sodium hyperpolarization- activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics; Belongs to the KCTD3 family. | 0.741 |
LRRC40 | LUM | ENSP00000359990 | ENSP00000266718 | Leucine-rich repeat-containing protein 40; Leucine rich repeat containing 40. | Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | 0.630 |