node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCB9 | OGFOD2 | ENSP00000440288 | ENSP00000228922 | ATP-binding cassette sub-family B member 9; ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C- terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored. Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. | 2-oxoglutarate and iron dependent oxygenase domain containing 2. | 0.637 |
ARL6IP4 | OGFOD2 | ENSP00000313422 | ENSP00000228922 | ADP-ribosylation factor-like protein 6-interacting protein 4; Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site. In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA. | 2-oxoglutarate and iron dependent oxygenase domain containing 2. | 0.576 |
JMJD4 | LRRC14 | ENSP00000355720 | ENSP00000292524 | 2-oxoglutarate and iron-dependent oxygenase JMJD4; Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1. | Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs to the PRAME family. LRRC14 subfamily. | 0.527 |
JMJD4 | OGFOD1 | ENSP00000355720 | ENSP00000457258 | 2-oxoglutarate and iron-dependent oxygenase JMJD4; Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1. | Prolyl 3-hydroxylase OGFOD1; Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro- 62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation; Belongs to the TPA1 family. | 0.685 |
JMJD4 | OGFOD2 | ENSP00000355720 | ENSP00000228922 | 2-oxoglutarate and iron-dependent oxygenase JMJD4; Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1. | 2-oxoglutarate and iron dependent oxygenase domain containing 2. | 0.685 |
LRRC14 | JMJD4 | ENSP00000292524 | ENSP00000355720 | Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs to the PRAME family. LRRC14 subfamily. | 2-oxoglutarate and iron-dependent oxygenase JMJD4; Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1. | 0.527 |
LRRC14 | OGFOD2 | ENSP00000292524 | ENSP00000228922 | Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs to the PRAME family. LRRC14 subfamily. | 2-oxoglutarate and iron dependent oxygenase domain containing 2. | 0.483 |
LRRC14 | TRMT2A | ENSP00000292524 | ENSP00000395738 | Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs to the PRAME family. LRRC14 subfamily. | tRNA (uracil-5-)-methyltransferase homolog A; May be involved in nucleic acid metabolism and/or modifications; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. | 0.646 |
OGFOD1 | JMJD4 | ENSP00000457258 | ENSP00000355720 | Prolyl 3-hydroxylase OGFOD1; Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro- 62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation; Belongs to the TPA1 family. | 2-oxoglutarate and iron-dependent oxygenase JMJD4; Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1. | 0.685 |
OGFOD1 | OGFOD2 | ENSP00000457258 | ENSP00000228922 | Prolyl 3-hydroxylase OGFOD1; Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro- 62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation; Belongs to the TPA1 family. | 2-oxoglutarate and iron dependent oxygenase domain containing 2. | 0.561 |
OGFOD2 | ABCB9 | ENSP00000228922 | ENSP00000440288 | 2-oxoglutarate and iron dependent oxygenase domain containing 2. | ATP-binding cassette sub-family B member 9; ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C- terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored. Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. | 0.637 |
OGFOD2 | ARL6IP4 | ENSP00000228922 | ENSP00000313422 | 2-oxoglutarate and iron dependent oxygenase domain containing 2. | ADP-ribosylation factor-like protein 6-interacting protein 4; Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site. In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA. | 0.576 |
OGFOD2 | JMJD4 | ENSP00000228922 | ENSP00000355720 | 2-oxoglutarate and iron dependent oxygenase domain containing 2. | 2-oxoglutarate and iron-dependent oxygenase JMJD4; Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1. | 0.685 |
OGFOD2 | LRRC14 | ENSP00000228922 | ENSP00000292524 | 2-oxoglutarate and iron dependent oxygenase domain containing 2. | Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs to the PRAME family. LRRC14 subfamily. | 0.483 |
OGFOD2 | OGFOD1 | ENSP00000228922 | ENSP00000457258 | 2-oxoglutarate and iron dependent oxygenase domain containing 2. | Prolyl 3-hydroxylase OGFOD1; Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro- 62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation; Belongs to the TPA1 family. | 0.561 |
OGFOD2 | PITPNM2 | ENSP00000228922 | ENSP00000322218 | 2-oxoglutarate and iron dependent oxygenase domain containing 2. | Membrane-associated phosphatidylinositol transfer protein 2; Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. | 0.510 |
OGFOD2 | TMEM218 | ENSP00000228922 | ENSP00000436596 | 2-oxoglutarate and iron dependent oxygenase domain containing 2. | Transmembrane protein 218; May be involved in ciliary biogenesis or function. | 0.542 |
OGFOD2 | TRMT2A | ENSP00000228922 | ENSP00000395738 | 2-oxoglutarate and iron dependent oxygenase domain containing 2. | tRNA (uracil-5-)-methyltransferase homolog A; May be involved in nucleic acid metabolism and/or modifications; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. | 0.805 |
OGFOD2 | WBP1 | ENSP00000228922 | ENSP00000233615 | 2-oxoglutarate and iron dependent oxygenase domain containing 2. | WW domain binding protein 1. | 0.573 |
OGFOD2 | WDR83 | ENSP00000228922 | ENSP00000402653 | 2-oxoglutarate and iron dependent oxygenase domain containing 2. | WD repeat domain-containing protein 83; Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activato [...] | 0.548 |