node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COL28A1 | COL6A2 | ENSP00000382356 | ENSP00000300527 | Collagen alpha-1(XXVIII) chain; May act as a cell-binding protein; Belongs to the VWA-containing collagen family. | Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein. | 0.535 |
COL28A1 | COL6A3 | ENSP00000382356 | ENSP00000295550 | Collagen alpha-1(XXVIII) chain; May act as a cell-binding protein; Belongs to the VWA-containing collagen family. | Collagen alpha-3(VI) chain; Collagen VI acts as a cell-binding protein. | 0.491 |
COL28A1 | COL8A1 | ENSP00000382356 | ENSP00000261037 | Collagen alpha-1(XXVIII) chain; May act as a cell-binding protein; Belongs to the VWA-containing collagen family. | Collagen alpha-1(VIII) chain; Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis. | 0.565 |
COL28A1 | P3H2 | ENSP00000382356 | ENSP00000316881 | Collagen alpha-1(XXVIII) chain; May act as a cell-binding protein; Belongs to the VWA-containing collagen family. | Prolyl 3-hydroxylase 2; Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens. Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1. Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline. Has no activity on substrates that lack 4- hydroxyproline in the third position. Belongs to the leprecan family. | 0.634 |
COL28A1 | P4HA1 | ENSP00000382356 | ENSP00000263556 | Collagen alpha-1(XXVIII) chain; May act as a cell-binding protein; Belongs to the VWA-containing collagen family. | Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. | 0.451 |
COL28A1 | P4HA2 | ENSP00000382356 | ENSP00000384999 | Collagen alpha-1(XXVIII) chain; May act as a cell-binding protein; Belongs to the VWA-containing collagen family. | Prolyl 4-hydroxylase subunit alpha-2; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. | 0.451 |
COL28A1 | P4HB | ENSP00000382356 | ENSP00000327801 | Collagen alpha-1(XXVIII) chain; May act as a cell-binding protein; Belongs to the VWA-containing collagen family. | Protein disulfide-isomerase; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chape [...] | 0.589 |
COL28A1 | PPIB | ENSP00000382356 | ENSP00000300026 | Collagen alpha-1(XXVIII) chain; May act as a cell-binding protein; Belongs to the VWA-containing collagen family. | Peptidyl-prolyl cis-trans isomerase B; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. | 0.637 |
COL6A2 | COL28A1 | ENSP00000300527 | ENSP00000382356 | Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein. | Collagen alpha-1(XXVIII) chain; May act as a cell-binding protein; Belongs to the VWA-containing collagen family. | 0.535 |
COL6A2 | COL6A3 | ENSP00000300527 | ENSP00000295550 | Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein. | Collagen alpha-3(VI) chain; Collagen VI acts as a cell-binding protein. | 0.994 |
COL6A2 | COL8A1 | ENSP00000300527 | ENSP00000261037 | Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein. | Collagen alpha-1(VIII) chain; Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis. | 0.666 |
COL6A2 | P3H2 | ENSP00000300527 | ENSP00000316881 | Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein. | Prolyl 3-hydroxylase 2; Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens. Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1. Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline. Has no activity on substrates that lack 4- hydroxyproline in the third position. Belongs to the leprecan family. | 0.726 |
COL6A2 | P4HA1 | ENSP00000300527 | ENSP00000263556 | Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein. | Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. | 0.494 |
COL6A2 | P4HA2 | ENSP00000300527 | ENSP00000384999 | Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein. | Prolyl 4-hydroxylase subunit alpha-2; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. | 0.515 |
COL6A2 | P4HB | ENSP00000300527 | ENSP00000327801 | Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein. | Protein disulfide-isomerase; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chape [...] | 0.572 |
COL6A2 | PPIB | ENSP00000300527 | ENSP00000300026 | Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein. | Peptidyl-prolyl cis-trans isomerase B; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. | 0.596 |
COL6A3 | COL28A1 | ENSP00000295550 | ENSP00000382356 | Collagen alpha-3(VI) chain; Collagen VI acts as a cell-binding protein. | Collagen alpha-1(XXVIII) chain; May act as a cell-binding protein; Belongs to the VWA-containing collagen family. | 0.491 |
COL6A3 | COL6A2 | ENSP00000295550 | ENSP00000300527 | Collagen alpha-3(VI) chain; Collagen VI acts as a cell-binding protein. | Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein. | 0.994 |
COL6A3 | COL8A1 | ENSP00000295550 | ENSP00000261037 | Collagen alpha-3(VI) chain; Collagen VI acts as a cell-binding protein. | Collagen alpha-1(VIII) chain; Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis. | 0.585 |
COL6A3 | P3H2 | ENSP00000295550 | ENSP00000316881 | Collagen alpha-3(VI) chain; Collagen VI acts as a cell-binding protein. | Prolyl 3-hydroxylase 2; Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens. Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1. Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline. Has no activity on substrates that lack 4- hydroxyproline in the third position. Belongs to the leprecan family. | 0.630 |