node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCKAR | PCDH7 | ENSP00000295589 | ENSP00000441802 | Cholecystokinin receptor type A; Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. | Protocadherin-7; Protocadherin 7. | 0.787 |
CCKAR | STIM2 | ENSP00000295589 | ENSP00000417569 | Cholecystokinin receptor type A; Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. | Stromal interaction molecule 2; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRA [...] | 0.736 |
FCGR1A | PCDH12 | ENSP00000358165 | ENSP00000231484 | High affinity immunoglobulin gamma Fc receptor I; High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. | Protocadherin-12, secreted form; Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions (By similarity). Acts as a regulator of cell migration, probably via increasing cell- cell adhesion. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions (By similarity). Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity). | 0.682 |
FCGR1A | PCDH7 | ENSP00000358165 | ENSP00000441802 | High affinity immunoglobulin gamma Fc receptor I; High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. | Protocadherin-7; Protocadherin 7. | 0.595 |
GJA1 | PCDH7 | ENSP00000282561 | ENSP00000441802 | Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli a [...] | Protocadherin-7; Protocadherin 7. | 0.935 |
GJA1 | RHOA | ENSP00000282561 | ENSP00000400175 | Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli a [...] | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.494 |
GTPBP1 | PCDH7 | ENSP00000216044 | ENSP00000441802 | GTP-binding protein 1; Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity). | Protocadherin-7; Protocadherin 7. | 0.825 |
GTPBP2 | PCDH7 | ENSP00000303997 | ENSP00000441802 | GTP binding protein 2. | Protocadherin-7; Protocadherin 7. | 0.827 |
PCDH12 | FCGR1A | ENSP00000231484 | ENSP00000358165 | Protocadherin-12, secreted form; Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions (By similarity). Acts as a regulator of cell migration, probably via increasing cell- cell adhesion. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions (By similarity). Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity). | High affinity immunoglobulin gamma Fc receptor I; High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. | 0.682 |
PCDH12 | PCDH7 | ENSP00000231484 | ENSP00000441802 | Protocadherin-12, secreted form; Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions (By similarity). Acts as a regulator of cell migration, probably via increasing cell- cell adhesion. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions (By similarity). Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity). | Protocadherin-7; Protocadherin 7. | 0.616 |
PCDH20-2 | PCDH7 | ENSP00000386653 | ENSP00000441802 | Protocadherin-20; Potential calcium-dependent cell-adhesion protein. | Protocadherin-7; Protocadherin 7. | 0.662 |
PCDH7 | CCKAR | ENSP00000441802 | ENSP00000295589 | Protocadherin-7; Protocadherin 7. | Cholecystokinin receptor type A; Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. | 0.787 |
PCDH7 | FCGR1A | ENSP00000441802 | ENSP00000358165 | Protocadherin-7; Protocadherin 7. | High affinity immunoglobulin gamma Fc receptor I; High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. | 0.595 |
PCDH7 | GJA1 | ENSP00000441802 | ENSP00000282561 | Protocadherin-7; Protocadherin 7. | Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli a [...] | 0.935 |
PCDH7 | GTPBP1 | ENSP00000441802 | ENSP00000216044 | Protocadherin-7; Protocadherin 7. | GTP-binding protein 1; Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity). | 0.825 |
PCDH7 | GTPBP2 | ENSP00000441802 | ENSP00000303997 | Protocadherin-7; Protocadherin 7. | GTP binding protein 2. | 0.827 |
PCDH7 | PCDH12 | ENSP00000441802 | ENSP00000231484 | Protocadherin-7; Protocadherin 7. | Protocadherin-12, secreted form; Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions (By similarity). Acts as a regulator of cell migration, probably via increasing cell- cell adhesion. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions (By similarity). Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity). | 0.616 |
PCDH7 | PCDH20-2 | ENSP00000441802 | ENSP00000386653 | Protocadherin-7; Protocadherin 7. | Protocadherin-20; Potential calcium-dependent cell-adhesion protein. | 0.662 |
PCDH7 | PPP1CA | ENSP00000441802 | ENSP00000326031 | Protocadherin-7; Protocadherin 7. | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] | 0.838 |
PCDH7 | RHOA | ENSP00000441802 | ENSP00000400175 | Protocadherin-7; Protocadherin 7. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.608 |