node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APIP | PDZD4 | ENSP00000379133 | ENSP00000377355 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. Belongs to the aldolase class II family. MtnB subfamily. | PDZ domain containing 4. | 0.467 |
BCAM | CNTN6 | ENSP00000270233 | ENSP00000407822 | Basal cell adhesion molecule; Laminin alpha-5 receptor. May mediate intracellular signaling. | Contactin-6; Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity); Belongs to the immunoglobulin superfamily. Contactin family. | 0.792 |
BCAM | FUT2 | ENSP00000270233 | ENSP00000387498 | Basal cell adhesion molecule; Laminin alpha-5 receptor. May mediate intracellular signaling. | Galactoside 2-alpha-L-fucosyltransferase 2; Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids. The resulting epitope plays a role in cell-cell interaction including host-microbe interaction. Mediates interaction with intestinal microbiota influencing its composition. Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway. | 0.495 |
BCAM | LAMA5 | ENSP00000270233 | ENSP00000252999 | Basal cell adhesion molecule; Laminin alpha-5 receptor. May mediate intracellular signaling. | Laminin subunit alpha-5; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | 0.946 |
BCAM | PDZD4 | ENSP00000270233 | ENSP00000377355 | Basal cell adhesion molecule; Laminin alpha-5 receptor. May mediate intracellular signaling. | PDZ domain containing 4. | 0.749 |
CNTN6 | BCAM | ENSP00000407822 | ENSP00000270233 | Contactin-6; Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity); Belongs to the immunoglobulin superfamily. Contactin family. | Basal cell adhesion molecule; Laminin alpha-5 receptor. May mediate intracellular signaling. | 0.792 |
CNTN6 | PDZD4 | ENSP00000407822 | ENSP00000377355 | Contactin-6; Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity); Belongs to the immunoglobulin superfamily. Contactin family. | PDZ domain containing 4. | 0.569 |
FUT2 | BCAM | ENSP00000387498 | ENSP00000270233 | Galactoside 2-alpha-L-fucosyltransferase 2; Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids. The resulting epitope plays a role in cell-cell interaction including host-microbe interaction. Mediates interaction with intestinal microbiota influencing its composition. Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway. | Basal cell adhesion molecule; Laminin alpha-5 receptor. May mediate intracellular signaling. | 0.495 |
FUT2 | PDZD4 | ENSP00000387498 | ENSP00000377355 | Galactoside 2-alpha-L-fucosyltransferase 2; Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids. The resulting epitope plays a role in cell-cell interaction including host-microbe interaction. Mediates interaction with intestinal microbiota influencing its composition. Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway. | PDZ domain containing 4. | 0.505 |
HSFX1 | PDZD4 | ENSP00000359444 | ENSP00000377355 | Heat shock transcription factor family, X-linked 1. | PDZ domain containing 4. | 0.472 |
IDH3G | PDZD4 | ENSP00000217901 | ENSP00000377355 | Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial; Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. | PDZ domain containing 4. | 0.469 |
LAMA5 | BCAM | ENSP00000252999 | ENSP00000270233 | Laminin subunit alpha-5; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | Basal cell adhesion molecule; Laminin alpha-5 receptor. May mediate intracellular signaling. | 0.946 |
LAMA5 | MCAM | ENSP00000252999 | ENSP00000264036 | Laminin subunit alpha-5; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | Cell surface glycoprotein MUC18; Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. | 0.425 |
LAMA5 | PDZD4 | ENSP00000252999 | ENSP00000377355 | Laminin subunit alpha-5; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | PDZ domain containing 4. | 0.547 |
LIPN | PDZD4 | ENSP00000383923 | ENSP00000377355 | Lipase member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers. | PDZ domain containing 4. | 0.528 |
MCAM | LAMA5 | ENSP00000264036 | ENSP00000252999 | Cell surface glycoprotein MUC18; Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. | Laminin subunit alpha-5; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | 0.425 |
MCAM | PDZD4 | ENSP00000264036 | ENSP00000377355 | Cell surface glycoprotein MUC18; Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. | PDZ domain containing 4. | 0.548 |
PDZD4 | APIP | ENSP00000377355 | ENSP00000379133 | PDZ domain containing 4. | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. Belongs to the aldolase class II family. MtnB subfamily. | 0.467 |
PDZD4 | BCAM | ENSP00000377355 | ENSP00000270233 | PDZ domain containing 4. | Basal cell adhesion molecule; Laminin alpha-5 receptor. May mediate intracellular signaling. | 0.749 |
PDZD4 | CNTN6 | ENSP00000377355 | ENSP00000407822 | PDZ domain containing 4. | Contactin-6; Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity); Belongs to the immunoglobulin superfamily. Contactin family. | 0.569 |