node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC18 | NUDT7 | ENSP00000343377 | ENSP00000268533 | Coiled-coil domain containing 18. | Peroxisomal coenzyme A diphosphatase NUDT7; Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'- ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA a [...] | 0.463 |
CCDC18 | PRADC1 | ENSP00000343377 | ENSP00000258083 | Coiled-coil domain containing 18. | Protease-associated domain-containing protein 1; Protease associated domain containing 1. | 0.588 |
CCDC18 | PRSS37 | ENSP00000343377 | ENSP00000297767 | Coiled-coil domain containing 18. | Probable inactive serine protease 37; Plays a role in male fertility (By similarity). May have a role in sperm migration or binding to zona-intact eggs (By similarity). Involved in the activation of the proacrosin/acrosin system ; Belongs to the peptidase S1 family. | 0.509 |
CCDC18 | SFXN4 | ENSP00000343377 | ENSP00000347924 | Coiled-coil domain containing 18. | Sideroflexin-4; Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria. Belongs to the sideroflexin family. | 0.471 |
CCDC18 | UACA | ENSP00000343377 | ENSP00000314556 | Coiled-coil domain containing 18. | Uveal autoantigen with coiled-coil domains and ankyrin repeats; Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity). | 0.477 |
CCDC18 | ZNF490 | ENSP00000343377 | ENSP00000311521 | Coiled-coil domain containing 18. | Zinc finger protein 490; May be involved in transcriptional regulation. | 0.430 |
KLRG2 | PRADC1 | ENSP00000339356 | ENSP00000258083 | Killer cell lectin like receptor G2. | Protease-associated domain-containing protein 1; Protease associated domain containing 1. | 0.400 |
LRRC56 | PRADC1 | ENSP00000270115 | ENSP00000258083 | Leucine-rich repeat-containing protein 56; Required for the assembly of dynein arms. Belongs to the LRRC56 family. | Protease-associated domain-containing protein 1; Protease associated domain containing 1. | 0.431 |
NUDT7 | CCDC18 | ENSP00000268533 | ENSP00000343377 | Peroxisomal coenzyme A diphosphatase NUDT7; Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'- ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA a [...] | Coiled-coil domain containing 18. | 0.463 |
NUDT7 | PRADC1 | ENSP00000268533 | ENSP00000258083 | Peroxisomal coenzyme A diphosphatase NUDT7; Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'- ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA a [...] | Protease-associated domain-containing protein 1; Protease associated domain containing 1. | 0.500 |
NUDT7 | PRSS37 | ENSP00000268533 | ENSP00000297767 | Peroxisomal coenzyme A diphosphatase NUDT7; Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'- ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA a [...] | Probable inactive serine protease 37; Plays a role in male fertility (By similarity). May have a role in sperm migration or binding to zona-intact eggs (By similarity). Involved in the activation of the proacrosin/acrosin system ; Belongs to the peptidase S1 family. | 0.432 |
PRADC1 | CCDC18 | ENSP00000258083 | ENSP00000343377 | Protease-associated domain-containing protein 1; Protease associated domain containing 1. | Coiled-coil domain containing 18. | 0.588 |
PRADC1 | KLRG2 | ENSP00000258083 | ENSP00000339356 | Protease-associated domain-containing protein 1; Protease associated domain containing 1. | Killer cell lectin like receptor G2. | 0.400 |
PRADC1 | LRRC56 | ENSP00000258083 | ENSP00000270115 | Protease-associated domain-containing protein 1; Protease associated domain containing 1. | Leucine-rich repeat-containing protein 56; Required for the assembly of dynein arms. Belongs to the LRRC56 family. | 0.431 |
PRADC1 | NUDT7 | ENSP00000258083 | ENSP00000268533 | Protease-associated domain-containing protein 1; Protease associated domain containing 1. | Peroxisomal coenzyme A diphosphatase NUDT7; Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'- ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA a [...] | 0.500 |
PRADC1 | PRSS37 | ENSP00000258083 | ENSP00000297767 | Protease-associated domain-containing protein 1; Protease associated domain containing 1. | Probable inactive serine protease 37; Plays a role in male fertility (By similarity). May have a role in sperm migration or binding to zona-intact eggs (By similarity). Involved in the activation of the proacrosin/acrosin system ; Belongs to the peptidase S1 family. | 0.622 |
PRADC1 | SFXN4 | ENSP00000258083 | ENSP00000347924 | Protease-associated domain-containing protein 1; Protease associated domain containing 1. | Sideroflexin-4; Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria. Belongs to the sideroflexin family. | 0.585 |
PRADC1 | UACA | ENSP00000258083 | ENSP00000314556 | Protease-associated domain-containing protein 1; Protease associated domain containing 1. | Uveal autoantigen with coiled-coil domains and ankyrin repeats; Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity). | 0.582 |
PRADC1 | ZNF490 | ENSP00000258083 | ENSP00000311521 | Protease-associated domain-containing protein 1; Protease associated domain containing 1. | Zinc finger protein 490; May be involved in transcriptional regulation. | 0.571 |
PRSS37 | CCDC18 | ENSP00000297767 | ENSP00000343377 | Probable inactive serine protease 37; Plays a role in male fertility (By similarity). May have a role in sperm migration or binding to zona-intact eggs (By similarity). Involved in the activation of the proacrosin/acrosin system ; Belongs to the peptidase S1 family. | Coiled-coil domain containing 18. | 0.509 |