node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BHLHE22 | PRDM13 | ENSP00000318799 | ENSP00000358217 | Class E basic helix-loop-helix protein 22; Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealiza [...] | PR domain zinc finger protein 13; May be involved in transcriptional regulation; Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.501 |
BHLHE22 | PTF1A | ENSP00000318799 | ENSP00000365687 | Class E basic helix-loop-helix protein 22; Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealiza [...] | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an impor [...] | 0.480 |
BHLHE22 | TLX3 | ENSP00000318799 | ENSP00000296921 | Class E basic helix-loop-helix protein 22; Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealiza [...] | T cell leukemia homeobox 3. | 0.452 |
CCNC | PRDM13 | ENSP00000428982 | ENSP00000358217 | Cyclin-C; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin- dependent kinase CDK8 that phosphoryla [...] | PR domain zinc finger protein 13; May be involved in transcriptional regulation; Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.503 |
IRS4 | PRDM13 | ENSP00000361202 | ENSP00000358217 | Insulin receptor substrate 4; Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin- stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kin [...] | PR domain zinc finger protein 13; May be involved in transcriptional regulation; Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.476 |
IRS4 | TLX3 | ENSP00000361202 | ENSP00000296921 | Insulin receptor substrate 4; Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin- stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kin [...] | T cell leukemia homeobox 3. | 0.425 |
PCMTD2 | PRDM13 | ENSP00000307854 | ENSP00000358217 | protein-L-isoaspartate O-methyltransferase domain containing 2; Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family. | PR domain zinc finger protein 13; May be involved in transcriptional regulation; Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.473 |
PCMTD2 | TLX3 | ENSP00000307854 | ENSP00000296921 | protein-L-isoaspartate O-methyltransferase domain containing 2; Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family. | T cell leukemia homeobox 3. | 0.420 |
PRDM11 | PRDM13 | ENSP00000480626 | ENSP00000358217 | PR domain-containing protein 11; May be involved in transcription regulation. Belongs to the class V-like SAM-binding methyltransferase superfamily. | PR domain zinc finger protein 13; May be involved in transcriptional regulation; Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.481 |
PRDM13 | BHLHE22 | ENSP00000358217 | ENSP00000318799 | PR domain zinc finger protein 13; May be involved in transcriptional regulation; Belongs to the class V-like SAM-binding methyltransferase superfamily. | Class E basic helix-loop-helix protein 22; Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealiza [...] | 0.501 |
PRDM13 | CCNC | ENSP00000358217 | ENSP00000428982 | PR domain zinc finger protein 13; May be involved in transcriptional regulation; Belongs to the class V-like SAM-binding methyltransferase superfamily. | Cyclin-C; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin- dependent kinase CDK8 that phosphoryla [...] | 0.503 |
PRDM13 | IRS4 | ENSP00000358217 | ENSP00000361202 | PR domain zinc finger protein 13; May be involved in transcriptional regulation; Belongs to the class V-like SAM-binding methyltransferase superfamily. | Insulin receptor substrate 4; Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin- stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kin [...] | 0.476 |
PRDM13 | PCMTD2 | ENSP00000358217 | ENSP00000307854 | PR domain zinc finger protein 13; May be involved in transcriptional regulation; Belongs to the class V-like SAM-binding methyltransferase superfamily. | protein-L-isoaspartate O-methyltransferase domain containing 2; Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family. | 0.473 |
PRDM13 | PRDM11 | ENSP00000358217 | ENSP00000480626 | PR domain zinc finger protein 13; May be involved in transcriptional regulation; Belongs to the class V-like SAM-binding methyltransferase superfamily. | PR domain-containing protein 11; May be involved in transcription regulation. Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.481 |
PRDM13 | PRDM2 | ENSP00000358217 | ENSP00000235372 | PR domain zinc finger protein 13; May be involved in transcriptional regulation; Belongs to the class V-like SAM-binding methyltransferase superfamily. | PR domain zinc finger protein 2; S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA- responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. | 0.489 |
PRDM13 | PRDM7 | ENSP00000358217 | ENSP00000496449 | PR domain zinc finger protein 13; May be involved in transcriptional regulation; Belongs to the class V-like SAM-binding methyltransferase superfamily. | Probable histone-lysine N-methyltransferase PRDM7; Probable histone methyltransferase. | 0.523 |
PRDM13 | PTF1A | ENSP00000358217 | ENSP00000365687 | PR domain zinc finger protein 13; May be involved in transcriptional regulation; Belongs to the class V-like SAM-binding methyltransferase superfamily. | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an impor [...] | 0.615 |
PRDM13 | SMYD5 | ENSP00000358217 | ENSP00000374152 | PR domain zinc finger protein 13; May be involved in transcriptional regulation; Belongs to the class V-like SAM-binding methyltransferase superfamily. | SET and MYND domain-containing protein 5; SMYD family member 5; Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.493 |
PRDM13 | TLX3 | ENSP00000358217 | ENSP00000296921 | PR domain zinc finger protein 13; May be involved in transcriptional regulation; Belongs to the class V-like SAM-binding methyltransferase superfamily. | T cell leukemia homeobox 3. | 0.527 |
PRDM2 | PRDM13 | ENSP00000235372 | ENSP00000358217 | PR domain zinc finger protein 2; S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA- responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. | PR domain zinc finger protein 13; May be involved in transcriptional regulation; Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.489 |