node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C1orf116 | C9orf152 | ENSP00000352447 | ENSP00000383456 | Specifically androgen-regulated gene protein; Putative androgen-specific receptor. Belongs to the SARG family. | Uncharacterized protein C9orf152; Chromosome 9 open reading frame 152. | 0.429 |
C1orf116 | HOMER1 | ENSP00000352447 | ENSP00000334382 | Specifically androgen-regulated gene protein; Putative androgen-specific receptor. Belongs to the SARG family. | Homer protein homolog 1; Postsynaptic density scaffolding protein. Binds and cross- links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER- associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic meta [...] | 0.829 |
C1orf116 | INIP | ENSP00000352447 | ENSP00000363360 | Specifically androgen-regulated gene protein; Putative androgen-specific receptor. Belongs to the SARG family. | SOSS complex subunit C; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. | 0.460 |
C1orf116 | NKX3-1 | ENSP00000352447 | ENSP00000370253 | Specifically androgen-regulated gene protein; Putative androgen-specific receptor. Belongs to the SARG family. | Homeobox protein Nkx-3.1; Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. Belongs to the NK-3 homeobox family. | 0.547 |
C1orf116 | OS9 | ENSP00000352447 | ENSP00000318165 | Specifically androgen-regulated gene protein; Putative androgen-specific receptor. Belongs to the SARG family. | Protein OS-9; Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4. | 0.543 |
C1orf116 | PRR15L | ENSP00000352447 | ENSP00000300557 | Specifically androgen-regulated gene protein; Putative androgen-specific receptor. Belongs to the SARG family. | Proline-rich protein 15-like protein; Proline rich 15 like; Belongs to the PRR15 family. | 0.454 |
C1orf116 | SCEL | ENSP00000352447 | ENSP00000302579 | Specifically androgen-regulated gene protein; Putative androgen-specific receptor. Belongs to the SARG family. | Sciellin; May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope. | 0.456 |
C1orf116 | ZNF888 | ENSP00000352447 | ENSP00000491567 | Specifically androgen-regulated gene protein; Putative androgen-specific receptor. Belongs to the SARG family. | Zinc finger protein 888; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.448 |
C9orf152 | C1orf116 | ENSP00000383456 | ENSP00000352447 | Uncharacterized protein C9orf152; Chromosome 9 open reading frame 152. | Specifically androgen-regulated gene protein; Putative androgen-specific receptor. Belongs to the SARG family. | 0.429 |
C9orf152 | PRR15L | ENSP00000383456 | ENSP00000300557 | Uncharacterized protein C9orf152; Chromosome 9 open reading frame 152. | Proline-rich protein 15-like protein; Proline rich 15 like; Belongs to the PRR15 family. | 0.587 |
HOMER1 | C1orf116 | ENSP00000334382 | ENSP00000352447 | Homer protein homolog 1; Postsynaptic density scaffolding protein. Binds and cross- links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER- associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic meta [...] | Specifically androgen-regulated gene protein; Putative androgen-specific receptor. Belongs to the SARG family. | 0.829 |
INIP | C1orf116 | ENSP00000363360 | ENSP00000352447 | SOSS complex subunit C; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. | Specifically androgen-regulated gene protein; Putative androgen-specific receptor. Belongs to the SARG family. | 0.460 |
NKX3-1 | C1orf116 | ENSP00000370253 | ENSP00000352447 | Homeobox protein Nkx-3.1; Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. Belongs to the NK-3 homeobox family. | Specifically androgen-regulated gene protein; Putative androgen-specific receptor. Belongs to the SARG family. | 0.547 |
OS9 | C1orf116 | ENSP00000318165 | ENSP00000352447 | Protein OS-9; Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4. | Specifically androgen-regulated gene protein; Putative androgen-specific receptor. Belongs to the SARG family. | 0.543 |
PRR15L | C1orf116 | ENSP00000300557 | ENSP00000352447 | Proline-rich protein 15-like protein; Proline rich 15 like; Belongs to the PRR15 family. | Specifically androgen-regulated gene protein; Putative androgen-specific receptor. Belongs to the SARG family. | 0.454 |
PRR15L | C9orf152 | ENSP00000300557 | ENSP00000383456 | Proline-rich protein 15-like protein; Proline rich 15 like; Belongs to the PRR15 family. | Uncharacterized protein C9orf152; Chromosome 9 open reading frame 152. | 0.587 |
PRR15L | ZNF888 | ENSP00000300557 | ENSP00000491567 | Proline-rich protein 15-like protein; Proline rich 15 like; Belongs to the PRR15 family. | Zinc finger protein 888; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.501 |
SCEL | C1orf116 | ENSP00000302579 | ENSP00000352447 | Sciellin; May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope. | Specifically androgen-regulated gene protein; Putative androgen-specific receptor. Belongs to the SARG family. | 0.456 |
ZNF888 | C1orf116 | ENSP00000491567 | ENSP00000352447 | Zinc finger protein 888; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Specifically androgen-regulated gene protein; Putative androgen-specific receptor. Belongs to the SARG family. | 0.448 |
ZNF888 | PRR15L | ENSP00000491567 | ENSP00000300557 | Zinc finger protein 888; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Proline-rich protein 15-like protein; Proline rich 15 like; Belongs to the PRR15 family. | 0.501 |