node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CNFN | CRCT1 | ENSP00000222032 | ENSP00000357779 | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family. | Cysteine rich C-terminal 1. | 0.601 |
CNFN | DMKN | ENSP00000222032 | ENSP00000342012 | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family. | Dermokine; May act as a soluble regulator of keratinocyte differentiation. | 0.432 |
CNFN | KRTDAP | ENSP00000222032 | ENSP00000339251 | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family. | Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. | 0.805 |
CNFN | LCE3D | ENSP00000222032 | ENSP00000357776 | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family. | Late cornified envelope protein 3D; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family. | 0.742 |
CNFN | SBSN | ENSP00000222032 | ENSP00000430242 | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family. | Suprabasin. | 0.606 |
CNFN | SPRR1A | ENSP00000222032 | ENSP00000357751 | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family. | Cornifin-A; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. | 0.526 |
CNFN | TGM3 | ENSP00000222032 | ENSP00000370867 | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family. | Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain; Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cros [...] | 0.667 |
CRCT1 | CNFN | ENSP00000357779 | ENSP00000222032 | Cysteine rich C-terminal 1. | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family. | 0.601 |
CRCT1 | KRTDAP | ENSP00000357779 | ENSP00000339251 | Cysteine rich C-terminal 1. | Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. | 0.638 |
CRCT1 | LCE3D | ENSP00000357779 | ENSP00000357776 | Cysteine rich C-terminal 1. | Late cornified envelope protein 3D; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family. | 0.834 |
CRCT1 | SBSN | ENSP00000357779 | ENSP00000430242 | Cysteine rich C-terminal 1. | Suprabasin. | 0.623 |
CRCT1 | SPRR1A | ENSP00000357779 | ENSP00000357751 | Cysteine rich C-terminal 1. | Cornifin-A; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. | 0.749 |
DMKN | CNFN | ENSP00000342012 | ENSP00000222032 | Dermokine; May act as a soluble regulator of keratinocyte differentiation. | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family. | 0.432 |
DMKN | KRTDAP | ENSP00000342012 | ENSP00000339251 | Dermokine; May act as a soluble regulator of keratinocyte differentiation. | Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. | 0.733 |
DMKN | SBSN | ENSP00000342012 | ENSP00000430242 | Dermokine; May act as a soluble regulator of keratinocyte differentiation. | Suprabasin. | 0.760 |
KRT2 | KRTDAP | ENSP00000310861 | ENSP00000339251 | Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). | Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. | 0.614 |
KRT2 | SBSN | ENSP00000310861 | ENSP00000430242 | Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). | Suprabasin. | 0.568 |
KRTDAP | CNFN | ENSP00000339251 | ENSP00000222032 | Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family. | 0.805 |
KRTDAP | CRCT1 | ENSP00000339251 | ENSP00000357779 | Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. | Cysteine rich C-terminal 1. | 0.638 |
KRTDAP | DMKN | ENSP00000339251 | ENSP00000342012 | Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. | Dermokine; May act as a soluble regulator of keratinocyte differentiation. | 0.733 |