node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC28B | SREK1IP1 | ENSP00000413017 | ENSP00000427401 | Coiled-coil domain-containing protein 28B; Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not seem to modulate assembly and function of mTORC1 complex. | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival. | 0.547 |
CREG2 | SREK1 | ENSP00000315203 | ENSP00000334538 | Protein CREG2; Cellular repressor of E1A stimulated genes 2. | Splicing regulatory glutamine/lysine-rich protein 1; Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity). | 0.418 |
CREG2 | SREK1IP1 | ENSP00000315203 | ENSP00000427401 | Protein CREG2; Cellular repressor of E1A stimulated genes 2. | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival. | 0.518 |
CREG2 | ZNF572 | ENSP00000315203 | ENSP00000319305 | Protein CREG2; Cellular repressor of E1A stimulated genes 2. | Zinc finger protein 572; May be involved in transcriptional regulation. | 0.498 |
CWC27 | PPWD1 | ENSP00000370460 | ENSP00000261308 | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. | Peptidylprolyl isomerase domain and WD repeat-containing protein 1; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be involved in pre-mRNA splicing ; Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily. | 0.663 |
CWC27 | SREK1IP1 | ENSP00000370460 | ENSP00000427401 | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival. | 0.528 |
NKAPD1 | SREK1IP1 | ENSP00000376767 | ENSP00000427401 | Uncharacterized protein NKAPD1; NKAP domain containing 1. | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival. | 0.502 |
NUP153 | SREK1IP1 | ENSP00000444029 | ENSP00000427401 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. [...] | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival. | 0.596 |
PPWD1 | CWC27 | ENSP00000261308 | ENSP00000370460 | Peptidylprolyl isomerase domain and WD repeat-containing protein 1; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be involved in pre-mRNA splicing ; Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily. | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. | 0.663 |
PPWD1 | SREK1IP1 | ENSP00000261308 | ENSP00000427401 | Peptidylprolyl isomerase domain and WD repeat-containing protein 1; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be involved in pre-mRNA splicing ; Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily. | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival. | 0.479 |
PRPF40A | SREK1 | ENSP00000386458 | ENSP00000334538 | Pre-mRNA-processing factor 40 homolog A; Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing; Belongs to the PRPF40 family. | Splicing regulatory glutamine/lysine-rich protein 1; Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity). | 0.729 |
PRPF40A | SREK1IP1 | ENSP00000386458 | ENSP00000427401 | Pre-mRNA-processing factor 40 homolog A; Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing; Belongs to the PRPF40 family. | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival. | 0.521 |
SMIM15 | SREK1IP1 | ENSP00000339324 | ENSP00000427401 | Small integral membrane protein 15. | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival. | 0.636 |
SREK1 | CREG2 | ENSP00000334538 | ENSP00000315203 | Splicing regulatory glutamine/lysine-rich protein 1; Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity). | Protein CREG2; Cellular repressor of E1A stimulated genes 2. | 0.418 |
SREK1 | PRPF40A | ENSP00000334538 | ENSP00000386458 | Splicing regulatory glutamine/lysine-rich protein 1; Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity). | Pre-mRNA-processing factor 40 homolog A; Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing; Belongs to the PRPF40 family. | 0.729 |
SREK1 | SREK1IP1 | ENSP00000334538 | ENSP00000427401 | Splicing regulatory glutamine/lysine-rich protein 1; Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity). | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival. | 0.791 |
SREK1 | ZNF572 | ENSP00000334538 | ENSP00000319305 | Splicing regulatory glutamine/lysine-rich protein 1; Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity). | Zinc finger protein 572; May be involved in transcriptional regulation. | 0.436 |
SREK1IP1 | CCDC28B | ENSP00000427401 | ENSP00000413017 | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival. | Coiled-coil domain-containing protein 28B; Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not seem to modulate assembly and function of mTORC1 complex. | 0.547 |
SREK1IP1 | CREG2 | ENSP00000427401 | ENSP00000315203 | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival. | Protein CREG2; Cellular repressor of E1A stimulated genes 2. | 0.518 |
SREK1IP1 | CWC27 | ENSP00000427401 | ENSP00000370460 | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival. | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. | 0.528 |