node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LHFPL5 | STT3A | ENSP00000498322 | ENSP00000376472 | LHFPL tetraspan subfamily member 5 protein; In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation (By similarity). | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A; Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation [...] | 0.556 |
LHFPL5 | TMC3 | ENSP00000498322 | ENSP00000352413 | LHFPL tetraspan subfamily member 5 protein; In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation (By similarity). | Transmembrane channel-like protein 3; Probable ion channel. | 0.427 |
OR6K6 | TMC3 | ENSP00000357126 | ENSP00000352413 | Olfactory receptor 6K6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Transmembrane channel-like protein 3; Probable ion channel. | 0.516 |
STT3A | LHFPL5 | ENSP00000376472 | ENSP00000498322 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A; Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation [...] | LHFPL tetraspan subfamily member 5 protein; In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation (By similarity). | 0.556 |
STT3A | TMC3 | ENSP00000376472 | ENSP00000352413 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A; Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation [...] | Transmembrane channel-like protein 3; Probable ion channel. | 0.455 |
SUMF2 | TMC3 | ENSP00000498402 | ENSP00000352413 | Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. | Transmembrane channel-like protein 3; Probable ion channel. | 0.449 |
SUMF2 | ZNF343 | ENSP00000498402 | ENSP00000482819 | Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. | Zinc finger protein 343; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.462 |
TMC3 | LHFPL5 | ENSP00000352413 | ENSP00000498322 | Transmembrane channel-like protein 3; Probable ion channel. | LHFPL tetraspan subfamily member 5 protein; In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation (By similarity). | 0.427 |
TMC3 | OR6K6 | ENSP00000352413 | ENSP00000357126 | Transmembrane channel-like protein 3; Probable ion channel. | Olfactory receptor 6K6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.516 |
TMC3 | STT3A | ENSP00000352413 | ENSP00000376472 | Transmembrane channel-like protein 3; Probable ion channel. | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A; Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation [...] | 0.455 |
TMC3 | SUMF2 | ENSP00000352413 | ENSP00000498402 | Transmembrane channel-like protein 3; Probable ion channel. | Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. | 0.449 |
TMC3 | UTS2B | ENSP00000352413 | ENSP00000340526 | Transmembrane channel-like protein 3; Probable ion channel. | Urotensin-2B; Potent vasoconstrictor; Belongs to the urotensin-2 family. | 0.440 |
TMC3 | ZNF343 | ENSP00000352413 | ENSP00000482819 | Transmembrane channel-like protein 3; Probable ion channel. | Zinc finger protein 343; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.537 |
UTS2B | TMC3 | ENSP00000340526 | ENSP00000352413 | Urotensin-2B; Potent vasoconstrictor; Belongs to the urotensin-2 family. | Transmembrane channel-like protein 3; Probable ion channel. | 0.440 |
ZNF343 | SUMF2 | ENSP00000482819 | ENSP00000498402 | Zinc finger protein 343; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. | 0.462 |
ZNF343 | TMC3 | ENSP00000482819 | ENSP00000352413 | Zinc finger protein 343; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Transmembrane channel-like protein 3; Probable ion channel. | 0.537 |