STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMCO4Transmembrane and coiled-coil domains 4; Belongs to the TMCO4 family. (634 aa)    
Predicted Functional Partners:
CDK5RAP1
CDK5 regulatory subunit-associated protein 1; Specifically inhibits CDK5 activation by CDK5R1; Belongs to the methylthiotransferase family. MiaB subfamily.
 
      0.692
VPS29
Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...]
    
 
 0.657
FAM187B
Protein FAM187B; Family with sequence similarity 187 member B.
      
 0.620
ETDB
Embryonic testis differentiation homolog B.
      
 0.580
ETDA
Embryonic testis differentiation homolog A.
      
 0.575
KPTN
KICSTOR complex protein kaptin; As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
    
   0.552
OR4F29
Olfactory receptor family 4 subfamily F member 29.
      
 0.507
OR4F16
Olfactory receptor 4F3/4F16/4F29; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.505
OR4F3
Olfactory receptor family 4 subfamily F member 3.
      
 0.480
FARSB
phenylalanyl-tRNA synthetase subunit beta; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
 
      0.468
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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