node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKH | TMEM263 | ENSP00000284268 | ENSP00000449785 | Progressive ankylosis protein homolog; Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter; Belongs to the ANKH family. | Transmembrane protein 263. | 0.449 |
BMP2 | TMEM263 | ENSP00000368104 | ENSP00000449785 | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 ; Belongs to the TGF-beta family. | Transmembrane protein 263. | 0.431 |
C1orf112 | TMEM263 | ENSP00000286031 | ENSP00000449785 | Uncharacterized protein C1orf112; Chromosome 1 open reading frame 112. | Transmembrane protein 263. | 0.441 |
GAS7 | TMCO1 | ENSP00000407552 | ENSP00000480514 | Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons. | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store. | 0.748 |
GAS7 | TMEM263 | ENSP00000407552 | ENSP00000449785 | Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons. | Transmembrane protein 263. | 0.431 |
MGAT4C | TCP11L2 | ENSP00000481096 | ENSP00000299045 | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; Glycosyltransferase that participates in the transfer of N- acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity). | T-complex protein 11-like protein 2; T-complex 11 like 2; Belongs to the TCP11 family. | 0.440 |
MGAT4C | TMEM263 | ENSP00000481096 | ENSP00000449785 | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; Glycosyltransferase that participates in the transfer of N- acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity). | Transmembrane protein 263. | 0.479 |
POLR3B | PRDM4 | ENSP00000228347 | ENSP00000228437 | DNA-directed RNA polymerase III subunit RPC2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the clef [...] | PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation; Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.474 |
POLR3B | TCP11L2 | ENSP00000228347 | ENSP00000299045 | DNA-directed RNA polymerase III subunit RPC2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the clef [...] | T-complex protein 11-like protein 2; T-complex 11 like 2; Belongs to the TCP11 family. | 0.570 |
POLR3B | TMEM263 | ENSP00000228347 | ENSP00000449785 | DNA-directed RNA polymerase III subunit RPC2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the clef [...] | Transmembrane protein 263. | 0.468 |
PRDM4 | POLR3B | ENSP00000228437 | ENSP00000228347 | PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation; Belongs to the class V-like SAM-binding methyltransferase superfamily. | DNA-directed RNA polymerase III subunit RPC2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the clef [...] | 0.474 |
PRDM4 | TCP11L2 | ENSP00000228437 | ENSP00000299045 | PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation; Belongs to the class V-like SAM-binding methyltransferase superfamily. | T-complex protein 11-like protein 2; T-complex 11 like 2; Belongs to the TCP11 family. | 0.432 |
PRDM4 | TMEM263 | ENSP00000228437 | ENSP00000449785 | PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation; Belongs to the class V-like SAM-binding methyltransferase superfamily. | Transmembrane protein 263. | 0.430 |
TCP11L2 | MGAT4C | ENSP00000299045 | ENSP00000481096 | T-complex protein 11-like protein 2; T-complex 11 like 2; Belongs to the TCP11 family. | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; Glycosyltransferase that participates in the transfer of N- acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity). | 0.440 |
TCP11L2 | POLR3B | ENSP00000299045 | ENSP00000228347 | T-complex protein 11-like protein 2; T-complex 11 like 2; Belongs to the TCP11 family. | DNA-directed RNA polymerase III subunit RPC2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the clef [...] | 0.570 |
TCP11L2 | PRDM4 | ENSP00000299045 | ENSP00000228437 | T-complex protein 11-like protein 2; T-complex 11 like 2; Belongs to the TCP11 family. | PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation; Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.432 |
TCP11L2 | TMEM263 | ENSP00000299045 | ENSP00000449785 | T-complex protein 11-like protein 2; T-complex 11 like 2; Belongs to the TCP11 family. | Transmembrane protein 263. | 0.558 |
TMCO1 | GAS7 | ENSP00000480514 | ENSP00000407552 | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store. | Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons. | 0.748 |
TMCO1 | TMEM263 | ENSP00000480514 | ENSP00000449785 | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store. | Transmembrane protein 263. | 0.409 |
TMEM263 | ANKH | ENSP00000449785 | ENSP00000284268 | Transmembrane protein 263. | Progressive ankylosis protein homolog; Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter; Belongs to the ANKH family. | 0.449 |