STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TRIM45Tripartite motif-containing protein 45; May act as a transcriptional repressor in mitogen- activated protein kinase signaling pathway; Ring finger proteins (580 aa)    
Predicted Functional Partners:
SPG20
Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis
      
 0.881
SORBS1
Sorbin and SH3 domain-containing protein 1; Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity)
   
 
 0.873
STAC
SH3 and cysteine-rich domain-containing protein; Probably involved in a neuron-specific signal transduction
      
 0.871
FCHSD2
FCH and double SH3 domains 2; F-BAR domain containing
      
 0.871
TRIM41
E3 ubiquitin-protein ligase TRIM41; Functions as an E3 ligase that catalyzes the ubiquitin- mediated degradation of protein kinase C; Ring finger proteins
      
 0.816
TRAT1
T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells
      
 0.764
TMLHE
Trimethyllysine dioxygenase, mitochondrial; Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML); Belongs to the gamma-BBH/TMLD family
      
 0.764
KIR3DL1
Killer cell immunoglobulin-like receptor 3DL1; Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis; CD molecules
      
 0.759
KIR2DL1
Killer cell immunoglobulin-like receptor 2DL1; Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis; CD molecules
      
 0.758
KIR3DL2
Killer cell immunoglobulin-like receptor 3DL2; Receptor on natural killer (NK) cells for HLA-A alleles. Inhibits the activity of NK cells thus preventing cell lysis; CD molecules
      
 0.734
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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