STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VWA5B2Von Willebrand factor A domain containing 5B2. (1242 aa)    
Predicted Functional Partners:
CLBA1
Uncharacterized protein CLBA1; Clathrin binding box of aftiphilin containing 1.
      
 0.609
RAB3A
Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...]
   
   0.520
FAM131A
Protein FAM131A; Family with sequence similarity 131 member A.
   
  
 0.486
KIF9
Kinesin-like protein KIF9; Kinesin family member 9.
   
  
 0.484
LRWD1
Leucine-rich repeat and WD repeat-containing protein 1; Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post- replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.
      
 0.482
C2orf81
Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81.
   
  
 0.478
MAP6D1
MAP6 domain-containing protein 1; May have microtubule-stabilizing activity; Belongs to the STOP family.
   
  
 0.459
RBM34
RNA binding motif protein 34.
    
 
 0.456
SH3RF3
E3 ubiquitin-protein ligase SH3RF3; Has E3 ubiquitin-protein ligase activity.
      
 0.440
LRATD2
Protein LRATD2; LRAT domain containing 2; Belongs to the LRATD family.
      
 0.429
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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