STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
WDR54WD repeat-containing protein 54; When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EGF receptor in WDR54-specific vesicle where it sustains the internalization and controls the degradation of the EGF receptor after EGF stimulation. (334 aa)    
Predicted Functional Partners:
OSCP1
Protein OSCP1; May be involved in drug clearance in the placenta.
   
   0.784
ITPRIPL1
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1; ITPRIP like 1.
   
  
 0.560
CCDC142
Coiled-coil domain containing 142.
      
 0.555
STAC3
SH3 and cysteine-rich domain-containing protein 3; Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels. Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membran [...]
    
   0.502
INO80B
INO80 complex subunit B; Induces growth and cell cycle arrests at the G1 phase of the cell cycle.
      
 0.477
C2orf81
Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81.
   
  
 0.471
WDR53
WD repeat domain 53; Belongs to the WD repeat WDR53 family.
      
 0.469
CCDC140
Coiled-coil domain-containing protein 140; CCDC140 long non-coding RNA.
      
 0.449
LBX2
Transcription factor LBX2; Putative transcription factor.
      
 0.445
CCDC107
Coiled-coil domain containing 107.
   
  
 0.438
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.