STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZFP28Zinc finger protein 28 homolog; May be involved in transcriptional regulation. May have a role in embryonic development; Zinc fingers C2H2-type (868 aa)    
Predicted Functional Partners:
CCDC43
Coiled-coil domain-containing protein 43; Coiled-coil domain containing 43; Belongs to the CCDC43 family
      
 0.642
TRAM1
Translocating chain-associated membrane protein 1; Stimulatory or required for the translocation of secretory proteins across the ER membrane; TLC domain containing
      
 0.538
TMEM182
Transmembrane protein 182
      
 0.524
TRAM1L1
Translocating chain-associated membrane protein 1-like 1; Stimulatory or required for the translocation of secretory proteins across the ER membrane; TLC domain containing
      
 0.521
C2CD4C
C2 calcium-dependent domain-containing protein 4C; C2 calcium dependent domain containing 4C; Belongs to the C2CD4 family
      
 0.513
RUNDC3B
Run domain-containing protein 3b; RUN domain containing 3B
      
 0.503
EIF2AK1
Eukaryotic translation initiation factor 2-alpha kinase 1; Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser- 48' and 'Ser-51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-se [...]
    
 
 0.498
ELFN2
Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing
      
 0.484
KIAA0020
Pumilio homology domain family member 6; Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells (By similarity)
      
 0.481
PPP1R18
Protein phosphatase 1 regulatory subunit 18; Phostensin; Isoform 1: May target protein phosphatase 1 to F-actin cytoskeleton
      
 0.471
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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