STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF117Zinc finger protein 117; May be involved in transcriptional regulation. (483 aa)    
Predicted Functional Partners:
SS18
Protein SSXT; Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner.
    
 
 0.770
SSX1
Protein SSX1; Could act as a modulator of transcription; Belongs to the SSX family.
      
 0.760
SSX2
SSX family member 2.
      
 0.744
ERV3-1
Endogenous retrovirus group 3 member 1 Env polyprotein; Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its fusogenic properties. It can inhibit cell growth through decrease expression of cyclin B1 and increased expression of p21 in vitro. TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediate [...]
   
 0.689
SSX5
Protein SSX5; Could act as a modulator of transcription.
      
 0.688
SSX4B
SSX family member 4B.
      
 0.648
SSX3
Protein SSX3; Could act as a modulator of transcription; Belongs to the SSX family.
      
 0.645
SSX4
Protein SSX4; Could act as a modulator of transcription.
      
 0.639
OR2L8
Olfactory receptor 2L8; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.506
MAGEB16
Melanoma-associated antigen B16; MAGE family member B16.
      
 0.479
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.