node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FANK1 | MALRD1 | ENSP00000357682 | ENSP00000412763 | Fibronectin type 3 and ankyrin repeat domains protein 1; Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis. | MAM and LDL-receptor class A domain-containing protein 1; Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis. | 0.504 |
FANK1 | ZNF554 | ENSP00000357682 | ENSP00000321132 | Fibronectin type 3 and ankyrin repeat domains protein 1; Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis. | Zinc finger protein 554; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.443 |
MALRD1 | FANK1 | ENSP00000412763 | ENSP00000357682 | MAM and LDL-receptor class A domain-containing protein 1; Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis. | Fibronectin type 3 and ankyrin repeat domains protein 1; Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis. | 0.504 |
MALRD1 | ZNF554 | ENSP00000412763 | ENSP00000321132 | MAM and LDL-receptor class A domain-containing protein 1; Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis. | Zinc finger protein 554; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.413 |
MYADM | ZNF554 | ENSP00000375649 | ENSP00000321132 | Myeloid associated differentiation marker; Belongs to the MAL family. | Zinc finger protein 554; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.478 |
PSPN | ZNF554 | ENSP00000245810 | ENSP00000321132 | Persephin; Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons. | Zinc finger protein 554; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.457 |
TRIM28 | ZNF383 | ENSP00000253024 | ENSP00000340132 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 383; May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways. | 0.570 |
TRIM28 | ZNF419 | ENSP00000253024 | ENSP00000388864 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 419; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.525 |
TRIM28 | ZNF554 | ENSP00000253024 | ENSP00000321132 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 554; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.690 |
TRIM28 | ZNF713 | ENSP00000253024 | ENSP00000416662 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 713; May be involved in transcriptional regulation. | 0.580 |
ZBTB3 | ZNF554 | ENSP00000501025 | ENSP00000321132 | Zinc finger and BTB domain-containing protein 3; May be involved in transcriptional regulation. | Zinc finger protein 554; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.422 |
ZNF383 | TRIM28 | ENSP00000340132 | ENSP00000253024 | Zinc finger protein 383; May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.570 |
ZNF383 | ZNF554 | ENSP00000340132 | ENSP00000321132 | Zinc finger protein 383; May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways. | Zinc finger protein 554; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.446 |
ZNF383 | ZNF713 | ENSP00000340132 | ENSP00000416662 | Zinc finger protein 383; May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways. | Zinc finger protein 713; May be involved in transcriptional regulation. | 0.458 |
ZNF419 | TRIM28 | ENSP00000388864 | ENSP00000253024 | Zinc finger protein 419; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.525 |
ZNF419 | ZNF554 | ENSP00000388864 | ENSP00000321132 | Zinc finger protein 419; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger protein 554; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.523 |
ZNF554 | FANK1 | ENSP00000321132 | ENSP00000357682 | Zinc finger protein 554; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Fibronectin type 3 and ankyrin repeat domains protein 1; Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis. | 0.443 |
ZNF554 | MALRD1 | ENSP00000321132 | ENSP00000412763 | Zinc finger protein 554; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | MAM and LDL-receptor class A domain-containing protein 1; Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis. | 0.413 |
ZNF554 | MYADM | ENSP00000321132 | ENSP00000375649 | Zinc finger protein 554; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Myeloid associated differentiation marker; Belongs to the MAL family. | 0.478 |
ZNF554 | PSPN | ENSP00000321132 | ENSP00000245810 | Zinc finger protein 554; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Persephin; Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons. | 0.457 |