searching ... STRING: functional protein association networks

Lzts3 - Leucine zipper putative tumor suppressor 3; May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses; Belongs to the LZTS3 family. [a.k.a. ENSMUSG00000037703, ENSMUSP00000037109, XM_017318204]

Pnn - Pinin; Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation [...] [a.k.a. NP_032917.2, BAE34129.1, AC153654]

Rab6b - Ras-related protein Rab-6B; Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (By similarity); Belongs to the small GTPase superfamily. Rab family. [a.k.a. Ras-related protein Rab-6B, D9Bwg0185e, R-MMU-392499]

Lemd3 - Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest (By similarity). [a.k.a. 380664, Q0VGU6, NP_001074662]

Tmeff1 - Tomoregulin-1; May inhibit NODAL and BMP signaling during neural patterning. Belongs to the tomoregulin family. [a.k.a. ENSMUSP00000118581, ENSMUST00000123476, XM_006537837.1]

Nlk - Serine/threonine-protein kinase NLK; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhi [...] [a.k.a. AL591177, NLK_MOUSE, Q5SYE6]

Hnrnph1 - Heterogeneous nuclear ribonucleoprotein H, N-terminally processed; This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG) (By similarity). [a.k.a. ENSMUST00000143301, ENSMUST00000132715, AAH56224.1]

Baalc - Brain and acute leukemia cytoplasmic protein; May play a synaptic role at the postsynaptic lipid rafts possibly through interaction with CAMK2A. [a.k.a. NP_542371.1, ENSMUSG00000022296, NM_080640]

Stx16 - Syntaxin-16; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network; Belongs to the syntaxin family. [a.k.a. NM_172675.4, UPI0001889B9D, ENSMUSP00000120279]

Map3k12 - Mitogen-activated protein kinase kinase kinase 12; Protein kinase which is part of a non-canonical MAPK signaling pathway. Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1. May be an activator of the JNK/SAPK pathway. [a.k.a. 26404, Map3k12-203, Map3k12-204]

Ntng1 - Netrin-G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites. [a.k.a. NM_030699, NP_597995.1, XM_011240294]

Kcna2 - Potassium voltage-gated channel subfamily A member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form funct [...] [a.k.a. XP_006501118, XP_006501117.1, XP_006501118.1]

Htr1b - 5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] [a.k.a. 5-HT-1B, CHEMBL3708691, AAI31952.1]

Otud7a - OTU domain-containing protein 7A; Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains. [a.k.a. OTU domain-containing protein 7A, NM_130880.1, ENSMUST00000177511]

Mmp16 - Matrix metalloproteinase-16; Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells (By similarity). [a.k.a. ENSMUSP00000121087, ENSMUSP00000116930, MT-MMP 3]

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