searching ... STRING: functional protein association networks

Pfkfb1 - 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; Synthesis and degradation of fructose 2,6-bisphosphate. [a.k.a. EC 3.1.3.46, F261_MOUSE, A2AFN0]

Trim32 - E3 ubiquitin-protein ligase TRIM32; Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin). May ubiquitinate BBS2 (By similarity). Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha. [a.k.a. R-MMU-1280218, 69807, XM_030253765.1]

Zdhhc16 - Palmitoyltransferase ZDHHC16; Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6. Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization. Also required for eye development. Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (By similarity). May play a role in DNA damage response. May be involved in apoptosis regulation. Involved in the proliferation of neural stem cells by re [...] [a.k.a. UPI000BAD5AD8, ENSMUST00000026154.8, DHHC-16]

B9d2 - B9 domain-containing protein 2; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes; Belongs to the B9D family. [a.k.a. ENSMUST00000205325, ENSMUST00000206913, Q3UK10]

Tanc1 - Protein TANC1; May be a scaffold component in the postsynaptic density. [a.k.a. XP_017174692.1, ENSMUST00000037526.10, XM_006500034.3]

Gtf3a - Transcription factor IIIA; Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III- dependent transcription and may also maintain the transcription of other genes (By similarity). Also binds the transcribed 5S RNA's (By similarity). [a.k.a. R-MMU-76061, ENSMUST00000132102.1, ENSMUSG00000016503]

Rbm8a2 - RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. [a.k.a. A0A0N4SUH6, ENSMUSP00000100599, UPI0000022920]

Prc1 - Protein regulator of cytokinesis 1; Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression. Belongs to the MAP65/ASE1 [...] [a.k.a. PRC1_MOUSE, NM_001285998, NP_001272926]

Col5a2 - Collagen alpha-2(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices. [a.k.a. NP_031763.2, R-MMU-186797, NP_031763]

Slc1a4 - Neutral amino acid transporter A; Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence (By similarity); Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A4 subfamily. [a.k.a. NP_061349, ASCT1, Q3UTP8]

Vps16 - Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late [...] [a.k.a. XR_374543.3, ENSMUSG00000027411, ENSMUSP00000115899]

Cnot3 - CCR4-NOT transcription complex subunit 3; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic [...] [a.k.a. XP_006539815.1, ENSMUST00000143085.7, XP_017177635.1]

Cckar - Cholecystokinin receptor type A; Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). [a.k.a. NP_033957.1, ENSMUST00000031093, UPI00005B205C]

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