searching ... STRING: functional protein association networks

Cyp3a25 - Cytochrome P450 3A25; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. [a.k.a. 56388, R-MMU-211981, XR_868677]

Cyp4a12b - Cytochrome P450 4A12B; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega- oxidation) of saturated and unsaturated fatty acids. May act as a major omega-hydroxylase for dodecanoic (lauric) acid in kidney. Participates [...] [a.k.a. NM_172306.2, R-MMU-2142691, NP_758510.2]

Cyp2c55 - Cytochrome P450 2C55; Metabolizes arachidonic acid mainly to 19- hydroxyeicosatetraenoic acid (HETE); Belongs to the cytochrome P450 family. [a.k.a. ENSMUSP00000025966, R-MMU-211981, Q9D816]

Pon3 - Serum paraoxonase/lactonase 3; Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents (By similarity). [a.k.a. ENSMUST00000125686, NP_766594, Paraoxonase 3]

Cyp4a12a - Cytochrome P450 4A12A; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega- oxidation) of saturated and unsaturated fatty acids. May act as a major omega-hydroxylase for dodecanoic (lauric) acid in kidney. Participates [...] [a.k.a. Cyp4a12a-201, R-MMU-2142691, NP_803125]

Cyp4a32 - Cytochrome P450, family 4, subfamily a, polypeptide 32; Belongs to the cytochrome P450 family. [a.k.a. R-MMU-2142691, EDL30641.1, XP_006502675.1]

Mug1 - Murinoglobulin-1; A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, f [...] [a.k.a. NP_032671, NM_008645.3, ENSMUST00000032228]

Prodh - Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. [a.k.a. Proline dehydrogenase, PROD_MOUSE, Prodh-202]

Slc22a7 - Solute carrier family 22 member 7; Mediates sodium-independent multispecific organic anion transport. High affinity transport of glutarate and prostaglandin E2 in a sodium-independent manner. Mediates also the uptake of alpha- ketoglutarate, p-aminohippuric acid, methotrexate, ochratoxin A, valproate, allopurinol and bumetanide. [a.k.a. 108114, Slc22a7-203, ENSMUST00000233575]

Reep6 - Receptor expression-enhancing protein 6; Required for correct function and survival of retinal photoreceptors. Required for retinal development. In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis. May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane. [a.k.a. NM_001204931.1, ENSMUST00000105357, Reep6-204]

Cfh - Complement factor H; Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradati [...] [a.k.a. Mud-1, Cfh-204, 2YBY]

Derl2 - Derlin-2; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the [...] [a.k.a. ENSMUSP00000136401, NM_001291147, Der1-like domain family, member 2]

Nat8f2 - N-acetyltransferase family 8 member 2; Probable acetyltransferase (Probable). Has no detectable histone acetyltransferase activity towards histone H3 or H4. Belongs to the camello family. [a.k.a. BC039773, Q9JIY9, Camello-like protein 2]

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