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The following proteins in
Homo sapiens
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101 query items
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1) '9606.ENSP00000241416':
ACVR2A - Activin receptor type-2A; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity).
[a.k.a. CAA44839.1, ENST00000404590, R-HSA-1502540]
2) '9606.ENSP00000359380':
SCD - Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By simi [...]
[a.k.a. stearoyl-CoA desaturase, CAA73998.1, 1.14.19.1]
3) '9606.ENSP00000453793':
MEIS2 - Homeobox protein Meis2; Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in [...]
[a.k.a. Homeobox protein Meis2, MEIS2-225, NM_002399]
4) '9606.ENSP00000283148':
UXS1 - UDP-glucuronic acid decarboxylase 1; Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.
[a.k.a. ENST00000283148, 80146, EC 4.1.1.35]
5) '9606.ENSP00000257290':
PDGFRA - Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointes [...]
[a.k.a. NP_006197.1, ENSP00000257290, E9PBH0]
6) '9606.ENSP00000348215':
SH3PXD2A - SH3 and PX domain-containing protein 2A; Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. Belongs to the SH3PXD2 family.
[a.k.a. SH3MD1, R-HSA-8941237, NP_055446.2]
7) '9606.ENSP00000298767':
WAPL - Wings apart-like protein homolog; Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Belongs to the WAPL family.
[a.k.a. ENST00000420749, R-HSA-2555396, XM_017015979.1]
8) '9606.ENSP00000408205':
LPAR4 - Lysophosphatidic acid receptor 4; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1- oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1- alkenyl-LPA.
[a.k.a. R-HSA-388396, LPA4, ENSP00000478261]
9) '9606.ENSP00000434364':
SLC6A5 - Sodium- and chloride-dependent glycine transporter 2; Sodium- and chloride-dependent glycine transporter. Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine- sensitive glycinergic synapses.
[a.k.a. GLYT2, ENST00000525748, XM_017018545.2]
10) '9606.ENSP00000453854':
SECISBP2L - Selenocysteine insertion sequence-binding protein 2-like; Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro.
[a.k.a. SLAN, SECISBP2L-207, ENST00000261847.7]
11) '9606.ENSP00000347134':
NET1 - Neuroepithelial cell-transforming gene 1 protein; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
[a.k.a. R-HSA-388396, NM_005863, Q7Z628]
12) '9606.ENSP00000321573':
DCBLD2 - Discoidin, CUB and LCCL domain containing 2.
[a.k.a. ENSP00000321573, XP_024309115.1, Q96PD2]
13) '9606.ENSP00000380565':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
14) '9606.ENSP00000327104':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
15) '9606.ENSP00000387462':
ZBTB10 - Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation.
[a.k.a. NP_076418.3, NM_001277145, ENSG00000205189]
16) '9606.ENSP00000368637':
SLC23A2 - Solute carrier family 23 member 2; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.
[a.k.a. AJ292318, R-HSA-196854, YSPL2]
17) '9606.ENSP00000218008':
ATP1B4 - Protein ATP1B4; May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit; Belongs to the X(+)/potassium ATPases subunit beta family.
[a.k.a. R-HSA-170834, R-HSA-162582, AF158383]
18) '9606.ENSP00000405674':
NOL7 - Nucleolar protein 7.
[a.k.a. CH471087, RARG-1, NOL7-202]
19) '9606.ENSP00000420608':
EMC1 - ER membrane protein complex subunit 1; Belongs to the EMC1 family.
[a.k.a. UPI0001B798B5, EMC1-204, HGNC:28957]
20) '9606.ENSP00000302629':
CHSY3 - Chondroitin sulfate synthase 3; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1.
[a.k.a. OMIM:609963, 2.4.1.226, NX_Q70JA7]
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