searching ... STRING: functional protein association networks

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The following proteins in Homo sapiens appear to match your input.
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101 query items

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1) '9606.ENSP00000245812':

ALKBH7 - Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial; May function as protein hydroxylase; can catalyze auto- hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does [...] [a.k.a. ENSP00000470562, NP_115682.1, AAQ89217.1]

2) '9606.ENSP00000380252':

NFE2L2 - Nuclear factor erythroid 2-related factor 2; Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles. In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex. In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, hetero [...] [a.k.a. NRF2, ENSP00000391291, ENST00000397063]

3) '9606.ENSP00000286918':

ANKRD9 - Ankyrin repeat domain 9. [a.k.a. ENST00000559404, R-HSA-8951664, ENSP00000286918]

4) '9606.ENSP00000440832':

CACFD1 - Calcium channel flower domain containing 1. [a.k.a. XP_011516488, BAC11691.1, uc011mdg.2]

5) '9606.ENSP00000301332':

KIFC2 - Kinesin-like protein KIFC2; May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites (By similarity). [a.k.a. NM_145754.3, Q96AC6, Kinesin-like protein KIFC2]

6) '9606.ENSP00000347665':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

7) '9606.ENSP00000322730':

ITM2C - Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). [a.k.a. NP_001274169.1, ENSP00000310976, AK056321]

8) '9606.ENSP00000404503':

BBC3 - Bcl-2-binding component 3, isoforms 3/4; [Isoform 3]: Does not affect cell growth. [a.k.a. NM_001127241, R-HSA-111453, 2M04]

9) '9606.ENSP00000334940':

GGN - Gametogenetin; May be involved in spermatogenesis. [a.k.a. XP_005258676, OTTHUMG00000182080, AAP31500.1]

10) '9606.ENSP00000221466':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

11) '9606.ENSP00000480314':

ZSWIM9 - Uncharacterized protein ZSWIM9; Zinc finger SWIM-type containing 9. [a.k.a. XM_006723204, ZSWIM9-203, XP_011525238]

12) '9606.ENSP00000247977':

FBXL12 - F-box/LRR-repeat protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia. [a.k.a. F-box and leucine-rich repeat protein 12, R-HSA-8951664, BAG52760.1]

13) '9606.ENSP00000312535':

LRFN4 - Leucine-rich repeat and fibronectin type-III domain-containing protein 4; Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity). Belongs to the LRFN family. [a.k.a. 78999, ENST00000531590.1, URS00008C0A59]

14) '9606.ENSP00000347896':

MBD6 - Methyl-CpG-binding domain protein 6; Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro). [a.k.a. XP_006719280, ENSP00000449749, MBD6-214]

15) '9606.ENSP00000311825':

CTBP2 - C-terminal-binding protein 2; Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. [a.k.a. XP_016871245, AL596261, 1488]

16) '9606.ENSP00000324560':

ULK1 - Serine/threonine-protein kinase ULK1; Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leadi [...] [a.k.a. XP_011537100.1, ENST00000321867.5, XP_011537100]

17) '9606.ENSP00000394390':

KCTD15 - BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain. [a.k.a. MGC25497, NM_024076.2, ENST00000588637]

18) '9606.ENSP00000366006':

UBIAD1 - UbiA prenyltransferase domain-containing protein 1; Prenyltransferase that mediates the formation of menaquinone- 4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independe [...] [a.k.a. uc001asg.4, R-HSA-196854, UBIAD1-203]

19) '9606.ENSP00000334849':

TMEM104 - Transmembrane protein 104; Belongs to the TMEM104 family. [a.k.a. CAB70787.1, ENSP00000463774, AK074029]

20) '9606.ENSP00000469686':

EGLN2 - Egl nine homolog 2; Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is [...] [a.k.a. ENSP00000469686, uc002opg.5, ENST00000593972]

101 query items

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